Sökning: "virus neutralization"
Visar resultat 16 - 20 av 43 avhandlingar innehållade orden virus neutralization.
16. Effects of galectins and antibodies in HIV infection; Novel Assays
Sammanfattning : The high variability of the HIV envelope glycoproteins (Env), and their heavy glycan coating, contributes to the limited host immune control. Still, broadly neutralizing antibodies (bnAbs) are found in some chronically infected HIV-infected individuals, which has spurred the research on antibody-based vaccines. LÄS MER
17. Humoral immunity during primate lentivirus infection : evaluation of B cell apoptosis and engineering of virus specific antibodies
Sammanfattning : The focus of this project was to evaluate the contribution of the humoral immunity in controlling infection with primate lentiviruses - an area which has implications both for vaccine design as well as for understanding of the pathogenesis of the disease. The first goal was to generate efficient neutralizing reagents which could be used for passive immunotherapy trials, preferably in the macaque system, and to investigate if peptide immunogens could elicit such antibodies. LÄS MER
18. Dynamics of the HIV-2-specific immunoglobulin A(IgA) response
Sammanfattning : Millions of lives are affected by infection with HIV, which causes AIDS if untreated. HIV transmission occurs primarily through sexual contact across mucosal surfaces. In the mucosal immune response, IgA is considered the first defense line against HIV invasion. LÄS MER
19. HIV-2 genetic evolution and viral dynamics
Sammanfattning : HIV-2 is less pathogenic and less transmissible compared to HIV-1. This is believed to be due to the lower viral load that is seen in HIV-2 infected patients. However, why this lower viral load is seen is not known. In this thesis we have investigated different aspects of HIV-2 in order to understand the pathogenesis of HIV-2 better. LÄS MER
20. Co-evolution of the HIV-1 R5 phenotype and the viral envelope glycoproteins
Sammanfattning : To gain entry into target cells, HIV-1 binds to CD4 via the viral glycoprotein gp120. This interac-tion initiates a series of events including binding of a coreceptor, CCR5 and/or CXCR4, and ulti-mately leads to gp41-mediated fusion of the viral and cell membranes. LÄS MER