Sökning: "viral replication"

Visar resultat 6 - 10 av 247 avhandlingar innehållade orden viral replication.

  1. 6. Real-time PCR studies of genotypes, mutations and replication of hepatitis B virus

    Författare :Sebastian Malmström; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis B virus; real-time PCR; lamivudine resistance; genotypes; replication;

    Sammanfattning : Infection with hepatitis B virus (HBV) is an important cause of liver disease and affects 350 million people worldwide, causing 600,000 deaths/year. Treatment includes interferon and nucleoside analogues (NAs) such as lamivudine, entecavir, and tenofovir. LÄS MER

  3. 7. Activity of tumor-antigens in polyomavirus replication

    Författare :Hongyun Li; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Tumor-Antigens; DNA Replication; Cell-cycle; Phosphorylation; J-domain; Biokemi; Biochemistry; Biokemi; Medical Virology; medicinsk virologi;

    Sammanfattning : Polyomavirus replication needs an active cell environment, and the viral DNA replication is cell cycle regulated. Tumor antigens (T-antigens) of mouse polyomavirus, especially large T-antigen, are necessary for the replication. LÄS MER

  4. 8. Studies on rotavirus replication

    Författare :Alexis Fuentes; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi; Biochemistry; Biokemi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Rotavirus is the leading cause of dehydrating diarrhea in infants and young children globally. In cells infected with rotavirus SA11 the synthesis of viral RNA and protein predominated already after a few hours. Cellular RNA remained intact, but viral mRNA was preferentially utilised for protein synthesis. LÄS MER

  5. 9. On gastrointestinal viral infections

    Författare :Thomas Beck-Friis; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; norovirus; rotavirus; SARS-CoV-2; gastroenteritis; diagnosis; elderly; epidemiology; humidity; COVID-19; genomic structural variation;

    Sammanfattning : Gastrointestinal viral infections cause considerable morbidity and mortality worldwide. Many factors influencing clinical presentation, disease severity, epidemiology, and transmission are not fully understood. LÄS MER

  7. 10. Novel Procedures for Identification and Characterization of Viral Proteases Inhibitors

    Författare :Angelica Ehrenberg; Helena Danielson; Celia Schiffer; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; drug discovery; viral proteases; inhibitors; Hepatitis C; NS3; cytomegalovirus; Biokemi; Biochemistry;

    Sammanfattning : Viral proteases are often considered to be attractive drug targets because of their crucial function in the viral replication machinery. In order to increase our knowledge of these important targets and to contribute to the discovery and development of new antiviral drugs, the proteases from hepatitis C virus (HCV) and human cytomegalovirus (HCMV) have been produced and their interactions with inhibitors and fragments have been characterized, using enzyme inhibition and SPR biosensor based interaction assay. LÄS MER