Avancerad sökning

Visar resultat 1 - 5 av 247 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Hepatitis B virus replication and integration

    Författare :Simon B. Larsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis B virus; replication; integration; HBV DNA; HBsAg;

    Sammanfattning : Chronic infection with hepatitis B virus (HBV) affects 240 million people worldwide and may cause liver disease including hepatocellular carcinoma (HCC). Initially patients have high levels of HBV DNA in their blood, no liver disease and express the e antigen (HBeAg). LÄS MER

  3. 2. Molecular characterization of the Tick-borne encephalitis virus : Environments and replication

    Författare :Wessam Melik; Magnus Johansson; Sonja Best; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Tick-borne encephalitis virus; molekylärgenetik; Molecular Genetics;

    Sammanfattning : The flavivirus genus is of major concern for world morbidity and mortality and includes viruses causing both encephalitic as well as hemorrhagic diseases. The incidence of Tick-borne encephalitis is increasing in many European countries and several reports have emphasized the expansion of the main vector, Ixodes ricinus. LÄS MER

  4. 3. HIV Persistence and Viral Reservoirs

    Författare :Arvid Edén; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; antiretroviral therapy; latency; cerebrospinal fluid; central nervous system; efavirenz; lopinavir; atazanavir; neopterin; viral decay;

    Sammanfattning : Although antiretroviral therapy (ART) can effectively inhibit replication of human immunodeficiency virus type 1 (HIV-1), the virus is able to persist in cellular and anatomical viral reservoirs. Latently infected resting memory CD4+ T-cells are an important cellular reservoir, and the central nervous system (CNS) an important anatomical reservoir for HIV-1 infection. LÄS MER

  5. 4. Evolution and viral mimicry of short linear motif-mediated interactions

    Författare :Filip Mihalič; Per Jemth; Leo James; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; phage display; protein-protein interactions; large-scale discovery; short linear motifs; viral mimcry; viral hijacking; Biokemi; Biochemistry; Medical Biochemistry; Medicinsk biokemi;

    Sammanfattning : Proteins are one of the most fundamental building blocks of life and their interactions regulate every cellular process. Historically they have been conceptualized as predominantly folded entities with well-defined secondary and tertiary structures. LÄS MER

  7. 5. Influenza A Virus : Spatial analysis of influenza genome trafficking and the evolution of the neuraminidase protein

    Författare :Dan Dou; Robert Daniels; Martin Schwemmle; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Influenza A virus; IAV; neuraminidase; NA; IAV genome trafficking; viral entry; viral replication; co-infection; antigenic drift; antigenic shift; NA assembly; transmembrane domain; evolution; Biochemistry; biokemi;

    Sammanfattning : Influenza A viruses (IAVs) are a common infectious agent that seasonally circulates within the human population that causes mild to severe acute respiratory infections. The severity of the infection is often related to how the virus has evolved with respect to the pre-existing immunity in the population. LÄS MER