Sökning: "viral hepatitis"

Visar resultat 1 - 5 av 90 avhandlingar innehållade orden viral hepatitis.

  1. 1. Hepatitis C virus. Aspects on natural history, antibody response, and viral quantification

    Författare :Martin Lagging; Göteborgs universitet; []
    Nyckelord :Hepatitis C virus; nosocomial infection; pseudotyped virus; fibrosis; viral quantification;

    Sammanfattning : Hepatitis C virus (HCV) is the major cause of parenterally transmitted non-A, non-B hepatitis, and is associated with chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Despite the screening of blood products nosocomial spread of HCV continues to occur. LÄS MER

  3. 2. Novel Procedures for Identification and Characterization of Viral Proteases Inhibitors

    Författare :Angelica Ehrenberg; Helena Danielson; Celia Schiffer; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; drug discovery; viral proteases; inhibitors; Hepatitis C; NS3; cytomegalovirus; Biokemi; Biochemistry;

    Sammanfattning : Viral proteases are often considered to be attractive drug targets because of their crucial function in the viral replication machinery. In order to increase our knowledge of these important targets and to contribute to the discovery and development of new antiviral drugs, the proteases from hepatitis C virus (HCV) and human cytomegalovirus (HCMV) have been produced and their interactions with inhibitors and fragments have been characterized, using enzyme inhibition and SPR biosensor based interaction assay. LÄS MER

  4. 3. Viral and host determinants in hepatitis B

    Författare :Hossein Sendi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The outcome of hepatitis B infection is highly variable, ranging from acute disease resulting in the elimination of infection to persistent infection that can lead to cirrhosis or hepatocellular carcinoma. The factors determining the outcome in an individual are not fully known but may be classified into viral and host factors. LÄS MER

  5. 4. Hepatitis C virus infection. Viral genotypes and factors promoting liver fibrosis

    Författare :Johan Westin; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatitis C virus; genotypes; epidemiology; liver fibrosis; histology; scoring; prognosis; alcohol; liver steatosis;

    Sammanfattning : Hepatitis C virus (HCV) is associated with chronic infection in a majority of infected individuals. Chronic hepatitis C may result in liver cirrhosis or hepatocellular cancer and is therefore considered a major health problem worldwide. LÄS MER

  7. 5. Genomic and transcriptomic profiles in chronic hepatitis B infection

    Författare :Johan Ringlander; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis B virus; hepatitis delta virus; integration; deep sequencing; cirrhosis; HCC;

    Sammanfattning : Chronic infection with hepatitis B virus (HBV) affects >250 million people globally and is the most common cause of hepatocellular carcinoma and liver cirrhosis worldwide. Approximately one million deaths each year are attributed to HBV infection. The virus is adapted to the human host and has developed mechanisms to evade immunity. LÄS MER