Sökning: "viral entry"

Visar resultat 16 - 20 av 62 avhandlingar innehållade orden viral entry.

1. 16. Tailored conjugates of N-acetylneuraminic acid and small molecules that block virus cell attachment and entry

   Författare :Emil Johansson; Mikael Elofsson; Niklas Arnberg; Geert-Jan Boons; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; N-acetylneuraminic acid; Neu5Ac; sialic acid; multivalency; Coxsackievirus A24v CVA24v ; Human adenovirus D37; D36; D26; HAdV-D37; HAdV-D26; HAdV-D36 ; 4-O-alkyl Neu5Ac; cryo-EM; branched pleconaril probes; conjunctivitis; organisk kemi; Organic Chemistry;

   Sammanfattning : Viruses are obligate intracellular parasites, unable to replicate without exploiting machinery andmaterials from host cells. Pandemics of viral diseases have had large impacts on human socieities and are continued threats to global health. LÄS MER

3. 17. Fusion activation in murine leukemia virus

   Författare :Michael Wallin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :MLV; retrovirus; virus entry; membrane fusion; disulphide isomerization;

   Sammanfattning : This thesis describes the fusion activation in Murine leukaemia virus (MLV). During entry of retroviruses into uninfected cells, the viral and cellular membranes fuse. The fusion process is mediated by the viral envelope protein composed of three SU and TM heterodimers. LÄS MER

4. 18. Molecular studies of the hepatitis C virus : the role of IRES activity for therapy response, and the impact of the non-structural protein

   Författare :Hannah Kim Lindström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Hepatitis C virus; IRES; viral translation; dual luciferase assay; therapy response; NS4B; topology; membrane rearrangements; membrane associated foci; Immunofluorescence; oligomerization; viral replication; bi-cistronic subgenomic replicon; replicon complex; mutations;

   Sammanfattning : Chronic hepatitis C can lead to life threatening conditions like cirrhosis, liver failure and hepatocellular carcinoma. There are an estimated 170 million chronic carriers of the hepatitis C virus (HCV) world wide, making it a serious global health problem. LÄS MER

5. 19. Human papillomavirus and cervical carcinoma in situ : implications for future screening

   Författare :Nathalie Ylitalo; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :cervical carcinoma in situ; human papillomavirus; HPV 16; quantitative PCR; archival smears; viral load; incubation period; smoking; oral contraceptive use;

   Sammanfattning : The principal aim of this thesis was to study the temporal relationship between human papillomavirus type 16 (HPV 16) infection and cervical carcinoma in situ, particularly focusing on the effect of viral load. Other aims were to study the role of additional factors, especially smoking and oral contraceptive use, in cervical carcinogenesis. LÄS MER

7. 20. Pathogenesis of an emerging pathogen : Crimean-Congo hemorrhagic fever virus

   Författare :Anne-Marie Connolly-Andersen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Epithelial cells represent the first barrier to viral infection and the site of viral entry and release is often intimately connected with viral spread and pathogenesis. The plasma membrane of epithelial cells is polarized into an apical and basolateral domain separated by tight junctions (TJs). LÄS MER