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Visar resultat 1 - 5 av 62 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Influenza A Virus : Spatial analysis of influenza genome trafficking and the evolution of the neuraminidase protein

    Författare :Dan Dou; Robert Daniels; Martin Schwemmle; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Influenza A virus; IAV; neuraminidase; NA; IAV genome trafficking; viral entry; viral replication; co-infection; antigenic drift; antigenic shift; NA assembly; transmembrane domain; evolution; Biochemistry; biokemi;

    Sammanfattning : Influenza A viruses (IAVs) are a common infectious agent that seasonally circulates within the human population that causes mild to severe acute respiratory infections. The severity of the infection is often related to how the virus has evolved with respect to the pre-existing immunity in the population. LÄS MER

  3. 2. Rift Valley fever : consequences of virus-host interactions

    Författare :Maria Baudin; Magnus Evander; Clas Ahlm; Göran Bucht; Tomas Bergström; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rift Valley fever; Rift Valley fever virus; viral haemorrhagic fever; miscarriage; entry; charge; carbohydrates; high-throughput screening; antiviral; cell-based assay; medicinsk virologi; Medical Virology;

    Sammanfattning : Rift Valley fever virus (RVFV) is a mosquito-borne virus which has the ability to infect a large variety of animals including humans in Africa and Arabian Peninsula. The abortion rate among these animals are close to 100%, and young animals develop severe disease which often are lethal. LÄS MER

  4. 3. Genetic vaccination against acute viral disease

    Författare :Marina N Fleeton; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Semliki Forest virus; Alphavirus. Influenza A virus; DNA vaccines. Influenza vaccine. Respiratory Syncytial Viruses; Louping Ill. Flavivirus Infections;

    Sammanfattning : This thesis describes the development of recombinant vaccines based on the Semliki Forest virus (SFV) expression system. Immunisation of mice with recombinant virus particles, a layered DNA/RNA plasmid vector, and recombinant self-replicating RNA were carried out and the protective effect of these recombinant vaccines against viral challenge were examined. LÄS MER

  5. 4. Induction of type I interferons and viral immunity

    Författare :Åsa Hidmark; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Virus-induced type I interferons (IFNα/β) are key mediators of innate immunity and important modulators of adaptive immunity. Early recognition of virus and induction of IFNα/β are important for limiting the spread of the virus. LÄS MER

  7. 5. Assembly and entry mechanisms of Semliki Forest virus

    Författare :Bernd Uwe Barth; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Semliki Forest virus; virus assembly; protein oligomerization; virus budding;

    Sammanfattning : The genomes of enveloped viruses are packaged into a core or nucleocapsid (NC) which is surrounded by a lipid membrane with spike proteins. These viruses mature by budding at a membrane of the host cell, usually the plasma membrane (PM), and penetrate into new ones by a virus-host membrane fusion event. LÄS MER