Sökning: "vinca"

Hittade 1 avhandling innehållade ordet vinca.

1. 1. Heterogeneity of leukemic cells with regard to daunorubicin accumulation and efflux : potential role in drug resistance

   Författare :Eva Knaust; Linköpings universitet; []
   Nyckelord :Drug resi stance. acute myeloid leukemia; flow cytometry; gene expression; transport kinetics; apoptosis; MEDICINE; MEDICIN;

   Sammanfattning : Cellular resistance to chemotherapy is a major cause of treatment failure in acute myelocytic leukemia (AML) and other malignancies. Drug resistance is multifactorial; the most studied mechanism being multidrug resistance (MDR), mediated by the P-glycoprotein (PPG), a transmembrane transport protein with a pump function, encoded by the mdr 1 gene. LÄS MER