Sökning: "vglut2"

Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet vglut2.

  1. 1. Immunocytochemical studies of excitatory amino acid neurotransmitters and transporters in the spinal cord and nucleus submedius

    Författare :Stefan Persson; Neurofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; neurophysiology; neuropsychology; Neurology; VGLUT2; VGLUT1; pain; somatosensory; thalamus; immunogold; glutamate; aspartate; dorsal horn; excitatory amino acids; spinal cord; neurofysiologi; Neurologi;

    Sammanfattning : The amino acid glutamate is today regarded as the main fast excitatory neurotransmitter in the central nervous system and a large body of evidence support that glutamate serves as a neurotransmitter in primary afferent terminals in the spinal cord. Previous evidence also suggests that the closely related amino acid aspartate may serve a similar role in some primary afferent terminals. LÄS MER

  3. 2. Motion and Emotion : Functional In Vivo Analyses of the Mouse Basal Ganglia

    Författare :Emma Arvidsson; Åsa Wallén-Mackenzie; Cecilia Flores; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dopamine; Basal Ganglia; Reward System; In Vivo Chronoamperometry; Optogenetics; Deep Brain Stimulation; Parkinson’s Disease; Addiction; Glutamate; Vesicular Glutamate Transporter; VGLUT2; Sex; Age; Subthalamic Nucleus; Striatum; Nucleus Accumbens; Ventral Tegmental Area;

    Sammanfattning : A major challenge in the field of neuroscience is to link behavior with specific neuronal circuitries and cellular events. One way of facing this challenge is to identify unique cellular markers and thus have the ability to, through various mouse genetics tools, mimic, manipulate and control various aspects of neuronal activity to decipher their correlation to behavior. LÄS MER

  4. 3. Across Borders : A Histological and Physiological Study of the Subthalamic Nucleus in Reward and Movement

    Författare :Nadine Schweizer; Åsa Wallén-Mackenzie; Dai Stephens; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; subthalamic nucleus; STN; basal ganglia; locomotion; hyperlocomotion; rearing; ventral tegmental area; VTA; dopamine; glutamate; vesicular glutamate transporter 2; Vglut2; Parkinson s disease; deep brain stimulation; subpopulation; conditional knock-out; optogenetic; co-expression; in situ hybridization; self-administration; reward behavior; mouse genetics;

    Sammanfattning : The basal ganglia are the key circuitry controlling movement and reward behavior. Both locomotion and reward-related behavior are also modified by dopaminergic input from the substantia nigra and the ventral tegmental area (VTA). LÄS MER

  5. 4. Signaling Mechanisms in the Neuronal Networks of Pain and Itch

    Författare :Katarzyna Rogoz; Klas Kullander; Malin Lagerström; Stephen McMahon; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mouse genetics; neuronal network; glutamate; sensory neuron; dorsal root ganglion; pain; itch; Neuroscience; Neurovetenskap; Molekylär genetik; Molecular Genetics;

    Sammanfattning : Glutamate is the essential neurotransmitters in pain pathways. The discovery of the vesicular glutamate transporters (VGLUT1-3) has been a fundamental step on the way to describe glutamate-dependent pain pathways. We used the Cre-lox system to construct conditional knockouts with deficient Vglut2 transmission in specific neuronal populations. LÄS MER

  7. 5. Functional Analysis of the Vesicular Glutamate Transporter 2 in Specific Neuronal Circuits of the Brain

    Författare :Karin Nordenankar; Åsa Wallén-Mackenzie; Rainer Spanagel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Addiction; amphetamine; affective behaviour; cocaine; cognitive behaviour; conditional knockout mouse; dopamine; operant self-administration; reward system; schizophrenia; Neuroscience; Neurovetenskap;

    Sammanfattning : A key issue in neuroscience is to determine the connection between neuronal circuits and behaviour. In the adult brain, all neuronal circuits include a glutamatergic component. LÄS MER