Sökning: "venous thrombosis"

Visar resultat 21 - 25 av 77 avhandlingar innehållade orden venous thrombosis.

  1. 21. Direct Thrombin Inhibitors in Treatment and Prevention of Venous Thromboembolism: Dose – Concentration – Response Relationships

    Författare :Marie Cullberg; Mats O. Karlsson; Ulf G. Eriksson; Nick H.G. Holford; Uppsala universitet; []
    Nyckelord :Pharmaceutical biosciences; Ximelagatran; pharmacokinetic; pharmacodynamic; activated partial thromboplastin time; utility function; dosing strategy; venous thromboembolism; NONMEM; Farmaceutisk biovetenskap;

    Sammanfattning : For prevention and treatment of thrombotic diseases with an anticoagulant drug it is important that an adequate dose is given to avoid occurrence or recurrence of thrombosis, without increasing the risk of bleeding and other adverse events to unacceptable levels. The aim of this thesis was to develop mathematical models that describe the dose-concentration (pharmacokinetic) and concentration-response (pharmacodynamic) relationships of direct thrombin inhibitors, in order to estimate optimal dosages for treatment and long-term secondary prevention of venous thromboembolism (VTE). LÄS MER

  3. 22. Venous thrombosis in children : the roles of vascular access and critical illness

    Författare :Åsa Östlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Venous thromboembolism (VT) is a rare event in the general pediatric population. However, the incidence in hospitalized children is higher and has increased dramatically reaching 58 per 10 000 children. The single most important risk factor for pediatric VT is the presence of a central venous catheter. LÄS MER

  4. 23. Venous thromboembolism with special focus on genetic and potential acquired risk factors

    Författare :SIGNY SVEINSDOTTIR; Malmö Klinisk koagulationsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Venous thromboembolism VTE ; Epidemiology; Risk factors; factor V leiden FVL ; Recurrence risk; Inflammation; renal function; Warfarin;

    Sammanfattning : Venous thromboembolism (VTE) is a relatively common cause of morbidity and mortality. It has an annual incidence of around 0.1- 0.3%. LÄS MER

  5. 24. Clinical aspects on treatment of deep venous thrombosis with a low molecular weight heparin

    Författare :Margareta Holmström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Dalteparin is a low molecular weight heparin (LMWH) with a mean mw of 4-6000 D. Compared to unfractionated heparin (UFH), a higher bioavailability, a longer half-life and a more predictable dose-response is achieved after subcutaneous injections. LÄS MER

  7. 25. Stroke in young adults in northern Sweden

    Författare :Bo Traberg Kristensen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cerebral venous thrombosis; cerebrospinal fluid dynamics; ischaemic stroke; young adults; epidemiology; fibrinolysis; homocysteine; cerebellar infarct; neuropsychology;

    Sammanfattning : Objectives. To study different aspects of cerebral venous and arterial occlusive disease including cerebrospinalfluid hydrodynamics, epidemiology, aetiology, genetics, metabolic and haemostatic disorders, andcognitive function in young adults in Northern Sweden.Methods. LÄS MER