Sökning: "vasoactive effects of insulin"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden vasoactive effects of insulin.

  1. 1. Regulation of lipid metabolism in rat and 3T3-L1 adipocytes; Cross-talk between Insulin, the neuro-peptides PACAP/VIP and with B1-integrins

    Författare :Lina Åkesson; Celiaki och diabetes; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; Endokrinologi; sekretion; diabetologi; secreting systems; Endocrinology; obesity; Insulin; diabetes;

    Sammanfattning : Type 2 Diabetes is a disorder that increases globally, but mainly in the western world. One of the hallmarks of Type 2 diabetes is insulin resistance in the target tissues of insulin action (adipose tissue, liver and skeletal muscle). In addition, most patients with Type 2 diabetes are obese. LÄS MER

  3. 2. Applications of microdialysis in studies of the adrenergic regulation of lipolysis in human skeletal muscle and adipose tissue

    Författare :Staffan Enoksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Human; in vivo; microdialysis; ethanol technique; lipolysis; blood flow; microcirculation; skeletal muscle; adipose tissue; adrenoceptors; insulin; forskolin; adenylyl cyclase; phosphodiesterases; glycerol; lactate.;

    Sammanfattning : Lipolysis, i.e., hydrolysis of triaeylglycerol to free fatty acids and glycerol, is a central process in lipid metabolism, and the regulation of lipid metabolism is altered in several common disorders, such as diabetes, obesity and atherosclerosis. LÄS MER

  4. 3. Studies of pancreatic islet microcirculation and insulin secretion in normal and diabetic rats

    Författare :Zhen Huang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :diabetes; islet; insulin; microcirculation; ethanol; blood flow; hypoglycemia; renin angiotensin system; statins;

    Sammanfattning : Type 2 diabetes is increasing globally. The disease is characterized not only by hyperglycemia, but also by insulin resistance with attendant dyslipidemia, hypertension and endothelial dysfunction. These aberrations may result in macrovascular disease, and deeply impact the longevity and quality of life in diabetic patients. LÄS MER

  5. 4. Cardiovascular and metabolic effects of endothelins in man : an experimental and clinical study

    Författare :Astrid Ottosson-Seeberger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :endothelin-1; big ET-1; C-terminal big ET-1 22-3 8 fragment; hemodynamic; blood flow; fractional extraction; conversion; plasma half-life; end-stage renal failure; ischemic heart disease; hemodialysis; high-flux membrane; glucose uptake; insulin sensitivity;

    Sammanfattning : Increased plasma concentrations of endothelin-1 (ET-1) and of its propeptide big endothelin-1 have been reported in diseases associated with endothelial dysfunction, cardiovascular remodelling and insulin resistance. In this thesis, we studied the hemodynamic effects of big ET-1 in healthy humans focusing on the mechanisms of the effects (study I-IV). LÄS MER

  7. 5. Assessment of microvascular and metabolic responses in the skin

    Författare :Fredrik Iredahl; Erik Tesselaar; Folke Sjöberg; Simon Farnebo; Sven Andersson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The general aim of this project was to develop experimental in vivo models that allow for minimally invasive investigations of responses in the skin to microvascular and metabolic provocations. The cutaneous microvasculature has emerged as a valuable model and been proposed to mirror the microcirculation in other organs. LÄS MER