Sökning: "vascular regulation"

Visar resultat 1 - 5 av 301 avhandlingar innehållade orden vascular regulation.

1. 1. Regulation of gene expression in the vascular wall

   Författare :Erik Larsson; Göteborgs universitet; []
   Nyckelord :smooth muscle; endothelium; angiogenesis; SRF; myocardin; LPP; gene regulation; genetics; microRNA;

   Sammanfattning : Blood vessel growth and function are closely related to a number of pathological conditions, including tumor angiogenesis, wound healing and atherosclerosis. Smooth muscle cells (SMC) and endothelial cells (EC), the two major constituents of the vascular wall, are both characterized by the expression of unique phenotypic marker genes, many of which have vital roles in blood vessel development and disease. LÄS MER

3. 2. Regulation of Angiogenesis

   Författare :Helena Larsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; angiogenesis; anti-angiogenesis; endostatin; latent antithrombin; prelatent antithrombin; Crk; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

   Sammanfattning : Angiogenesis is the formation of new blood vessels from pre-existing ones. New blood vessel formation is fundamental in processes such as reproduction, embryonic development and wound healing. Growth of neoplasms is accompanied by increased angiogenesis. This thesis describes cellular and molecular mechanisms of importance for angiogenesis. LÄS MER

4. 3. Lymphatic Vascular Morphogenesis : From Progenitors to Functional Vessels

   Författare :Nina Daubel; Taija Mäkinen; Markus Affolter; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lymphatic vasculature; morphogenesis; lymphvasculogenesis; mesentery; lymphatic capillary;

   Sammanfattning : The lymphatic vasculature is an important part of the circulatory system and crucial for normal functioning and maintenance of tissues. Yet, our understanding of the processes underlying lymphatic development and homeostasis are surprisingly limited. LÄS MER

5. 4. Transcriptional and post-transcriptional regulation of vascular smooth muscle cell phenotype - Implications for vascular disease states

   Författare :Azra Alajbegovic; Molekylär kärlfysiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Vascular smooth muscle cells VSMC ; cell phenotype; microRNA; Aneurysm; hypertension; Actin polymerization; GATA6; MRTFA; Vascular disease;

   Sammanfattning : As the world population is pushing toward 8 billion, cardiovascular diseases (CVD) remain the leading cause of death worldwide, representing 30% of all global deaths. A large body of work has recognized that smooth muscle cells (SMCs) surrounding the blood vessels play a prominent role in the development and progression of cardiovascular diseases. LÄS MER

7. 5. CD93 in regulation of vascular function and tumour progression

   Författare :Kalyani Vemuri; Anna Dimberg; Pipsa Saharinen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD93; Tumour angiogenesis; Vascular permeability; Endothelial junctions; Cancer; Glioblastoma; Metastasis;

   Sammanfattning : To achieve successful vascular targeting in cancer, a better understanding of the molecular mechanisms that lead to tumour vascular abnormalities is required.  The transmembrane protein CD93 is highly expressed in the vasculature of several tumours including glioblastoma and has emerged as a potential anti-angiogenic target. LÄS MER