Sökning: "vascular grafts"

Visar resultat 11 - 15 av 52 avhandlingar innehållade orden vascular grafts.

  1. 11. Vascular Wall Responses to Bypass Grafting - Studies in Mice

    Författare :Klas Österberg; Göteborgs universitet; []
    Nyckelord :Intimal hyperplasia; graft stenosis; smooth muscle cells; mice; cellular recruitment;

    Sammanfattning : Abstract Vein grafts are frequently used in bypass surgery for treatment of coronary artery disease and lower limb ischemia. Unfortunately the long-term patency is impaired by vein graft stenoses due to intimal hyperplasia (IH). It is assumed that exaggerated intimal thickening is initiated by vessel wall injuries or local flow disturbances. LÄS MER

  3. 12. Studies on vascular remodeling in acute coronary artery disease

    Författare :Fei Chen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Atherosclerosis; unstable angina; matrix metalloproteinase; apoptosis; angiogenesis; remodeling;

    Sammanfattning : Atherosclerosis is an arterial disease, characterized by endothelial dysfunction, vascular inflammation, and lipid accumulation in the vessel wall. Unstable coronary syndroms may be initiated by rupture of the atherosclerotic plaque, which may be caused by activation of matrix metalloproteinases (MMPs), apoptosis and angiogenesis. LÄS MER

  4. 13. Platelet Activation and Inhibition in Connection with Vascular Stents

    Författare :Kjeld Christensen; Rolf Larsson; Sten Husted; Uppsala universitet; []
    Nyckelord :Medicine; platelets; inhibition; activation; stents; ACS; Medicin;

    Sammanfattning : This thesis describes the Chandler loop, which makes it possible to conduct studies in vitro of molecular and cellular interactions between whole blood and stents. It was possible to monitor activation and inhibition of the cascades systems, leukocytes and platelets by combining different platelet inhibitors and heparin coating of stents. LÄS MER

  5. 14. Vascular Endothelial Growth Factor (VEGF) and Peripheral Nerve Regeneration

    Författare :Mariann Sondell; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Schwann cell; SCG; rat; peripheral nerve regeneration; neuropilin-1; nerve repair; mouse; growth factor; flk-1; axonal outgrowth; DRG; VEGF; Animal physiology; Djurfysiologi;

    Sammanfattning : This thesis concerns vascular endothelial growth factor (VEGF) and its possible role as a neurotrophic factor. I have investigated the effect of VEGF on neurons in culture but also in vivo, following a crush lesion of the sciatic nerve, and following nerve repair. LÄS MER

  7. 15. Tissue engineering in blood vessels

    Författare :Gisela Helenius; Göteborgs universitet; []
    Nyckelord :tissue engineering; vascular graft; endothelial cells; smooth muscle cells; thrombogenicity; mechanical properties; scaffold; bacterial cellulose;

    Sammanfattning : Severely occluded coronary- and peripheral arteries, caused by atherosclerotic plaques, are treated with bypass surgery. Autologous veins are the most commonly used replacement graft. Among the patients that need a vascular bypass, 5-10% lack appropriate replacement veins due to previous surgery of bad quality of the vessels. LÄS MER