Sökning: "vascular endothelial growth factor"
Visar resultat 11 - 15 av 184 avhandlingar innehållade orden vascular endothelial growth factor.
11. Cardiovascular effects of growth hormone. Studies in genetically engineered mice
Sammanfattning : The general aim of this thesis was to enhance the understanding on the relationships between growth hormone (GH) and cardiovascular disease using genetically engineered mice. More specifically the effects of GH on blood pressure (BP), vascular and cardiac function, atherosclerosis and autonomic control of heart rate were studied. LÄS MER
12. Vascular endothelial growth factor B-role in metabolism, lipotoxicity and disease
Sammanfattning : Vascular Endothelial Growth Factor B (VEGF-B) was previously shown to control lipid uptake from the bloodstream via the endothelium into tissue cells, and when ablating Vegfb, intra-tissue lipid accumulation was reduced. However, very little is known regarding the metabolic role of VEGF-B in physiologic, or pathophysiologic conditions. LÄS MER
13. Growth factor regulation of the urokinase plasminogen activator (uPA) system in human endometrium, and the significance of uPA receptor activation in endometrial angiogenesis
Sammanfattning : The purpose of this thesis was to examine the role of growth factors and the urokinase plasminogen activator (uPA) system in human endometrial angiogenesis. Growth factors as well as progesterone increased expression of the main inhibitor of uPA (PAI-1) in primary cultures of endometrial stromal cells. LÄS MER
14. Role of extracellular retention of platelet-derived growth factor-B. Functions in development and disease
Sammanfattning : During development, the cell secretes growth and differentiation factors (GDFs) to the surrounding microenvironment. These factors are often key regulators of organogenesis and embryogenesis. Several GDFs carry sequences that mediate specific interaction with molecules of the extracellular matrix (ECM) that surrounds the cell. LÄS MER
15. Effects of Ischaemia on the Neuroretina and Retinal Blood Vessels
Sammanfattning : Identification of the intracellular signal transduction pathways activated in retinal ischaemia may be important in revealing novel pharmacological targets. The retinal blood vessels are key organs in circulatory failure, and in this work the retinal vasculature was therefore examined separately from the neuroretina. LÄS MER