Sökning: "vascular endothelial growth factor VEGF"

Visar resultat 16 - 20 av 128 avhandlingar innehållade orden vascular endothelial growth factor VEGF.

1. 16. Vascular endothelial growth factor B-role in metabolism, lipotoxicity and disease

   Författare :Annika Mehlem; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Vascular Endothelial Growth Factor B (VEGF-B) was previously shown to control lipid uptake from the bloodstream via the endothelium into tissue cells, and when ablating Vegfb, intra-tissue lipid accumulation was reduced. However, very little is known regarding the metabolic role of VEGF-B in physiologic, or pathophysiologic conditions. LÄS MER

3. 17. Tamoxifen response in primary breast cancer with special reference to tumour-specific VEGF-A and VEGFR2

   Författare :Lisa Rydén; Lund Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytology; oncology; cancerology; Cytologi; onkologi; cancer; prognosis; randomised controlled trial; adjuvant tamoxifen treatment; vascular endothelial growth factor receptor 2; breast cancer; vascular endothelial growth factor A;

   Sammanfattning : Background: Treatment of primary breast cancer is individualised and adjuvant systemic treatment is delivered to most patients after surgery. Oestrogen receptor (ER) status and progesterone receptor status (PR) can define patients who would benefit from adjuvant endocrine therapy with tamoxifen (TAM) alone or as chemo-endocrine therapy. LÄS MER

4. 18. Molecular Mechanisms in Endothelial Cell Differentiation

   Författare :Emma Rennel; Pär Gerwins; Lena Claesson-Welsh; Ian Zachary; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; angiogenesis; FGF-2; VEGF-A; signal transduction; in vitro angiogenesis assay; immortalized brain endothelial cells; H-Ras; tetracycline-regulated gene expression; microarray; telomerase immortalized human microvascular endothelial cells; differentiation; Patologi; Pathology; Patologi;

   Sammanfattning : Angiogenesis is the formation of new blood vessels from the pre-existing blood vessels. Blood vessels are composed of endothelial cells and supporting musculature. Angiogenesis is regulated by numerous soluble ligands and by cell-matrix interactions. LÄS MER

5. 19. Studies of the vascular endothelial growth factors, VEGFs, and their receptors, focusing on VEGF-B

   Författare :Birgitta Olofsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :vasculogenesis; angiogenesis; VEGF; VEGF-B; VEGF receptors; neuropilin;

   Sammanfattning : The inner lining of all blood- and lymphatic vessels are composed of endothelial cells. Their growth and differentiation are in part regulated by polypeptide growth factors and their receptors. LÄS MER

7. 20. Growth factor regulation of the urokinase plasminogen activator (uPA) system in human endometrium, and the significance of uPA receptor activation in endometrial angiogenesis

   Författare :Tove Sandberg; Lund Obstetrik och gynekologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstetrics; endothelial cell migration; angiogenesis; uPA:PAI-1 complex; uPAR; TGF-beta; PAI-1; EGF; uPA; Growth factor; gynaecology; andrology; reproduction; sexuality; Obstetrik; gynekologi; andrologi; reproduktion; sexualitet;

   Sammanfattning : The purpose of this thesis was to examine the role of growth factors and the urokinase plasminogen activator (uPA) system in human endometrial angiogenesis. Growth factors as well as progesterone increased expression of the main inhibitor of uPA (PAI-1) in primary cultures of endometrial stromal cells. LÄS MER