Sökning: "vascular dysfunction"

Visar resultat 1 - 5 av 186 avhandlingar innehållade orden vascular dysfunction.

1. 1. Vascular Dysfunction in Stroke and CADASIL

   Författare :Anna Stenborg; Lars Lind; Andreas Terent; Toste Länne; Uppsala universitet; []
   Nyckelord :Internal medicine; stroke; CADASIL; endothelium; vasodilation; Invärtesmedicin;

   Sammanfattning : Cerebrovascular disease (CVD) is strongly linked to hypertension and generally occurs later in life than coronary artery disease (CAD). Three quarters of the patients with symptomatic CVD are above 65 years of age. The risk factors are the same for CVD and CAD, but the relative importance of the vascular risk factors differs greatly. LÄS MER

3. 2. Biomarkers of vascular function and structure in young healthy adults

   Författare :Paul Pettersson-Pablo; Anita Hurtig-Wennlöf; Torbjörn Nilsson; Lars Breimer; Anders Larsson; Örebro universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; atherosclerosis; vascular function; vascular structure; body composition; age; inflammation; clinical chemistry; biomarker;

   Sammanfattning : Atherosclerosis is a disease affecting the blood vessels in the body. Its pathophysiologic mechanisms involve infiltration of the vessel walls by fatty matter and immune cells. This process is slow, starting in childhood but typically not manifesting as symptomatic disease until late adulthood (after 60 years of age). LÄS MER

4. 3. Vascular Effects of P2 Receptors. Changes in Congestive Heart Failure

   Författare :Malin Malmsjö; Lund Medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; congestive heart failure; pyrimidine; purine; P2 receptor; vasodilatation; vasoconstriction; hyperpolarisation; EDHF; NO; Vascular; endothelium; Cardiovascular system; Kardiovaskulära systemet;

   Sammanfattning : Extracellular nucleotides induce dilatation and constriction of blood vessels by activation of P2 receptors. In this thesis the vasomotor effects of P2 receptor activation were studied in the rat mesenteric artery, and their changes in congestive heart failure (CHF) were evaluated using in vitro pharmacology, electrophysiology and competitive RT-PCR. LÄS MER

5. 4. Integration of signalling in smooth muscle caveolae

   Författare :Yulia Shakirova; Cellulär biomekanik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Caveola; caveolin; detrusor; cavin; smooth muscle contractility; remodelling; NO; vascular dysfunction; smooth muscle; erectile dysfunction;

   Sammanfattning : Caveolae and lipid rafts are plasma membrane microdomains that are considered to play a role in cellular signalling. Caveolins and cavins as well as cholesterol are required for the structure and function of caveolae. The papers summarized in this thesis examine the role of caveolae in smooth muscle function. LÄS MER

7. 5. Hemodynamic Effects of Lung Function Optimization in Experimental Acute Respiratory Distress Syndrome

   Författare :Arnoldo Santos; Anders Larsson; Fernando Suarez-Sipmann; John Marini; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute respiratory distress syndrome; Lung protective ventilation; Mechanical ventilation; Open lung approach; Pulmonary heart disease; Pulmonary vascular mechanics; Pulmonary vascular dysfunction; Pulse wave analysis; Right ventricular dysfunction; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care; Fysiologi; Physiology;

   Sammanfattning : Acute Respiratory Distress Syndrome (ARDS) is a severe pulmonary inflammation affecting thousands of patients every year in Sweden and has a mortality of 30-50%. Mechanical ventilation (MV) is usually necessary, but could per se augment the inflammation and contribute to mortality. LÄS MER