Sökning: "var-genes"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet var-genes.

  1. 1. Towards understanding the SURFIN protein family and var genes in Plasmodium falciparum

    Författare :Fingani Annie Mphande; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Plasmodium falciparum, the parasite responsible for severe malaria, has been shown to use different protein families for its survival and proliferation within the human host. Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), a protein responsible for the cytoadherence of parasitized red blood cells (pRBCs) has been implicated in severe disease. LÄS MER

  3. 2. Endothelial cytoadherence, rosetting and virulence in Plasmodium falciparum malaria

    Författare :Andreas Heddini; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Plasmodium falciparum; malaria; endothelial adhesion; erythrocyte rosetting; PECAM- 1 CID3 1; immunoglobulins; cerebral malaria; PfEMP- 1; var-genes;

    Sammanfattning : Excessive sequestration of Plasmodium falciparum-infected erythrocytes (pRBC) and uninfected erythrocytes directly blocks the microcirculation and precipitates severe symptoms from the affected organ and is thereby thought to be responsible for the severe complications which may occur during P. falciparum infection. LÄS MER

  4. 3. Periodontal disease in adolescents with Down syndrome

    Författare :Monica Barr Agholme; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Plasmodium falciparum; malaria; erythrocyte rosetting; humoral immunity; glycosaminoglycan; heparan sulfate; heparin; ABO blood groups; Plasmodium falciparum erythrocyte membrane protein 1; var genes;

    Sammanfattning : Characterization of virulence factors in P. falciparum malaria is essential in order to identify new therapeutic and prophylactic targets. Rosette formation, the binding of uninfected red blood cells to parasite-infected red blood cells, is a P. falciparum virulence phenotype associated with severe clinical manifestations, e. LÄS MER

  5. 4. Carbohydrate-mediated adhesion in Plasmodium falciparum malaria

    Författare :Antonio Barragan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Plasmodium falciparum; malaria; erythrocyte rosetting; humoral immunity; glycosaminoglycan; heparan sulfate; heparin; ABO blood groups; Plasmodium falciparum erythrocyte membrane protein 1; var genes;

    Sammanfattning : Characterization of virulence factors in P. falciparum malaria is essential in order to identify new therapeutic and prophylactic targets. Rosette formation, the binding of uninfected red blood cells to parasite-infected red blood cells, is a P. falciparum virulence phenotype associated with severe clinical manifestations, e. LÄS MER

  7. 5. Surface antigens and virulence in Plasmodium falciparum malaria

    Författare :Johan Normark; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Plasmodium falciparum is an intracellular protozoan that may cause severe forms of malaria. It is a major world health hazard and reaps the highest toll among the children and pregnant mothers of the developing world. An Anopheles mosquito vector injects the pathogen when taking a blood meal. LÄS MER