Sökning: "var PfEMP1"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden var PfEMP1.

  1. 1. Towards understanding the SURFIN protein family and var genes in Plasmodium falciparum

    Författare :Fingani Annie Mphande; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Plasmodium falciparum, the parasite responsible for severe malaria, has been shown to use different protein families for its survival and proliferation within the human host. Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), a protein responsible for the cytoadherence of parasitized red blood cells (pRBCs) has been implicated in severe disease. LÄS MER

  3. 2. Antigenic variation and virulence in Plasmodium falciparum malaria : studies on the surface protein PfEMP1

    Författare :Karin Blomqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Approximately 40% of the world’s population is at risk of contracting malaria, a disease caused by the intracellular protozoan Plasmodium. The species Plasmodium falciparum is responsible for the majority of severe morbidity and mortality. LÄS MER

  4. 3. Genomic and transcripto variation in blood stage Plasmodium falciparum

    Författare :Bobo Mok; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Antigenic variation; comparative genomic hybridization CGH ; copy number polymorphism CNP ; microarray; P. falciparum; PfEMP1; subtelomeric regions; segmental duplication; switching; var;

    Sammanfattning : Malaria research has entered a postgenomic era since October 2002, when the complete genomic sequence of Plasmodium falciparum strain 3D7 was published. A massive amount of information generated by the P. falciparum genome project has facilitated the development of many novel platforms for profiling different levels of biological aspects. LÄS MER

  5. 4. Variant antigens at the infected red cell surface in Plasmodium falciparum malaria

    Författare :Victor Fernandez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Plasmodium falciparum; blood stages; variant antigens; var PfEMP1; rif RIFIN; adhesive phenotypes; cytoadherence; endothelial receptor; PECAM-1 CD31; rosetting; heparan sulphate;

    Sammanfattning : Disease severity in Plasmodium falciparum infections is, to a large extent, a consequence of the parasite's efficient escape from die human host defences. Sequestration and antigenic variation are two evasion mechanisms featured by P.falciparum. LÄS MER

  7. 5. Pursuing the fever trail : pathogenesis of blood-stage P. falciparum malaria and pregnancy

    Författare :Niloofar Rasti; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Plasmodium falciparum; malaria; erythrocytes; pregnancy; Uganda; placental sequestration; cytoadhesion; PfEMP1; var2csa; antigenic variation; live-cell proteomic.;

    Sammanfattning : The burden of the most virulent form of human malarias, Plasmodium falciparum, is concentrated among young children and pregnant women in sub-Saharan Africa. Excessive sequestration of parasite-infected red blood cells (pRBCs) in the capillary beds of different organs is the hallmark of P. LÄS MER