Avancerad sökning

Hittade 5 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Vasodilator actions of EDHF and anandamide

    Författare :David Andersson; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vanilloid receptors; afferent neurons; anandamide; cannabinoids; potassium channels; hyperpolarization; vasodilation; Vascular endothelium; arteries; airways; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Sammanfattning : Vasodilator responses to endothelium-derived hyperpolarizing factor (EDHF) and anandamide in isolated arteries were investigated. A combination of the potassium channel blockers charybdotoxin and apamin inhibits EDHF-mediated relaxations. LÄS MER

  3. 2. Sensory neuropeptides and nitric oxide in nasal vascular regulation

    Författare :Johan Rinder; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Sensory nerves; neuropeptides; nasal mucosa; nitric oxide; vascular regulation; acoustic rhinometry; NK1-receptors; CGRP-receptors; vanilloid receptors; capsaicin; lactic acid; exercise; a-adrenoceptor agonists; pig; human.;

    Sammanfattning : The role of sensory neuropeptides and nitric oxide in vascular regulation was investigated in the pig nasal mucosa in vivo using arterial blood flow measurements and acoustic rhinometry for analysis of capacitance function. Moreover, the effects of heavy physical exercise, a-adrenoceptor agonists, nitric oxide synthase (NOS) inhibition, L-arginine, nitric oxide (NO) gas, histamine and capsaicin on nasal cavity NO levels and nasal cavity volume, were investigated in healthy subjects. LÄS MER

  4. 3. Endogenous activators of the pain receptor TRPV1 From cell to man

    Författare :Pouya Movahed Rad; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; cannabinoids; capsazepine; N-acylethanolamines; anandamide; blood Circulation; vasodilation; humans; calcitonin Gene-related Peptide; capsaicin; neurogenic inflammation; nociceptors; TRPV1 protein; pain;

    Sammanfattning : N-acylethanolamines (NAEs) belong to a growing family of endogenous signalling molecules acting on a variety of receptors and ion channels. In 1992, it was reported that the N-acylethanolamine anandamide is present in the brain and activates the central cannabinoid (CB) receptor. LÄS MER

  5. 4. Biosynthesis and physiological functions of N-acyl amino acids

    Författare :Dominik Paweł Waluk; Mary C. Hunt; David Merkler; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; molekylärgenetik; Molecular Genetics;

    Sammanfattning : N-acyl amino acids are lipid signalling molecules that have recently been identified in biological systems. These lipids are structurally related to the endocannabinoids, although they do not activate cannabinoid receptors. LÄS MER

  7. 5. Neuropeptide release in the rat dorsal horn in models of persistent pain : effects of opioids

    Författare :Abdullahi Warsame Afrah; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Axotomy; Inflammation; Long term potentiation; Capsaicin; Opioids; Cholecystokinin; Substance P; Glutamate; NMDA; Spinal cord; Microdialysis; Radioimmunoassay.;

    Sammanfattning : Nerve injury and tissue inflammation may lead to exaggerated responses to both noxious stimuli (hyperalgesia) and innocuous stimuli (allodynia). Altered release pattems of neurotransmitters in the dorsal hom of the spinal cord have been suggested to contribute to hyperalgesia and allodynia. LÄS MER