Sökning: "valproate"
Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet valproate.
1. Treatments and outcomes in bipolar disorder
Sammanfattning : Bipolar disorder is defined by recurring mood episodes and patients have a markedly increased risk of suicide. Pharmacological and psychological treatments for bipolar disorder have proven efficacy in clinical trials yet the generalizability of current evidence to routine clinical practice is contested. LÄS MER
2. Bipolar disorder and lithium treatment : etiologies and consequences
Sammanfattning : Bipolar disorder is a chronic disabling psychiatric disorder marked by episodic disruptive mood swings, accompanied by disturbances in cognition and behavior. Without effective treatment, bipolar disorder can have devastating consequences, including suicide. LÄS MER
3. Epidemiological studies of medication use and effectiveness in bipolar disorder
Sammanfattning : In the last decades, new treatments for bipolar disorder (BD) have emerged, prompting a decrease in the use of lithium – the former “gold standard” for relapse prevention, and increasing the possibilities for individualized treatment. The aims of this thesis were to: 1) explore the use of relapse prevention in the early phases of bipolar illness, 2) add to the current knowledge concerning the comparative effectiveness of various pharmacological maintenance treatments, including combination therapies, and 3) explore the use of benzodiazepines and non-benzodiazepine hypnotics (so called Z-drugs) in BD. LÄS MER
4. Common mechanism for teratogenicity of antiepileptic drugs : Drug-induced embryonic arrhythmia and hypoxia-reoxygenation damage
Sammanfattning : The Antiepilptic drugs (AEDs) phenytoin (PHT), carbamazepine (CBZ), phenobarbital (PB), tri- and dimethadione (TMD and DMD) are known teratogens having a common malformation pattern in human and animal studies. This thesis was designed chiefly to test a hypothesis correlating the teratogenicity of these AEDs to episodes of pharmacologically induced embryonic arrhythmia and hypoxia-reoxygenation damage. LÄS MER
5. Juvenile myoclonic epilepsy : clinical, genetic, clinical pharmacological, and neurophysiological studies
Sammanfattning : Juvenile myoclonic epilepsy (JME) has been considered to be a discrete phenotype. Evidence from segregation analysis and twin studies suggest that JME is a genetically determined disease, and two previous linkage studies of separately ascertained kindreds have suggested that a JME locus, EJM 1, resides on chromosome 6p close to the HLA region. LÄS MER