Sökning: "usher"
Visar resultat 16 - 20 av 24 avhandlingar innehållade ordet usher.
16. Retinal function in deaf-blind syndromes
Sammanfattning : A variety of disorders can cause retinal degeneration and hearing impairment, and it is of great value to have an early diagnosis since there is a large variation in phenotype and prognosis both within and between the different disorders. The general aim of this thesis was to characterize the retinal function, to describe the phenotype, and – where appropriate – to relate the phenotype to genotype in patients with combined visual and hearing impairment. LÄS MER
17. Synthesis of substituted Ring-Fused 2-Pyridones and applications in chemical biology
Sammanfattning : Antibiotics have been extensively used to treat bacterial infections since Alexander Fleming’s discovery of penicillin 1928. Disease causing microbes that have become resistant to antibiotic drug therapy are an increasing public health problem. LÄS MER
18. Entrepreneurial Well-Being : The Payoff Structure of Business Creation
Sammanfattning : Given the importance of entrepreneurship to individuals and to society, and given that the individual has come to be seen as not only an important function of social and economic processes but also as an important end of these processes, the link between entrepreneurship and well-being requires further investigation. To that end, this thesis provides a solid framework for understanding and measuring well-being in entrepreneurship, and a comprehensive theoretical and empirical examination of the intimate relationship between these two phenomena. LÄS MER
19. Model-Based Optimization of Clinical Trial Designs
Sammanfattning : General attrition rates in drug development pipeline have been recognized as a necessity to shift gears towards new methodologies that allow earlier and correct decisions, and the optimal use of all information accrued throughout the process. The quantitative science of pharmacometrics using pharmacokinetic-pharmacodynamic models was identified as one of the strategies core to this renaissance. LÄS MER
20. Peptidomimetics based on ring-fused 2-pyridones : probing pilicide function in uropathogenic E. coli and identification of Aβ-peptide aggregation inhibitors
Sammanfattning : This thesis describes the synthesis and biological evaluation of highly substituted, ring-fused 2-pyridones. The utility of the bicyclic 2-pyridones to gain fundamental insights into the disease processes of bacterial infections and Alzheimer’s disease has been investigated. LÄS MER