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Visar resultat 1 - 5 av 15 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Steroid metabolism in human reproductive organs

    Författare :Anna Helena Karypidis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Androgens are involved in the development of prostate cancer. Both UGT2B17 and CYP7B1 are involved in the metabolism of androgens and are highly abundant in the prostate. Deletion of the UGT2B17 gene is associated with low or undetectable urinary testosterone levels. LÄS MER

  3. 2. Sex steroid metabolism and body composition

    Författare :Charlotte Swanson; Göteborgs universitet; []
    Nyckelord :UDP glucuronosyltranferases; polymorphisms; androgens; glucuronidated androgen metabolites; fat mass; bone; metabolic risk factors; population study;

    Sammanfattning : Background: The bioactive androgens testosterone (T) and dihydrotestosterone (DHT) regulate bone and fat mass in men. The effects of androgens are largely determined by the rate of their synthesis and inactivation. LÄS MER

  4. 3. Urinary steroid profiles in doping testing : in relation to natural variation and drug administration

    Författare :Jenny Mullen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : To detect doping with endogenous steroids, such as testosterone, biomarkers in urine are measured. These biomarkers include testosterone and some metabolically related steroids. The measured steroids are combined into ratios and together they make up the steroid profile. LÄS MER

  5. 4. Studies on the extracellular matrix of the dysfunctional pelvic floor

    Författare :Marie Westergren Söderberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Pelvic floor; pelvic organ prolapse; stress urinary incontinence; extracellular matrix; collagen; SLRPs; decorin; lumican; fibromodulin; elastin associated proteins; fibrillin-1; fibulin-5; sex steroid hormone receptors; ER; PR; AR;

    Sammanfattning : Objective: Pelvic floor dysfunction cause impaired quality of life of many women and is one of the most common reasons for gynaecological surgery on benign indications. Little is known about the pelvic floor extracellular matrix as a pre-requisite for mechanical sustainability through vaginal delivery, age and hormonal changes. LÄS MER

  7. 5. Endocrine profile in female Olympic athletes : of importance for physical performance and impact on anti-doping testing

    Författare :Emma Eklund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Endogenous androgens and insulin-like growth factor-I (IGF-I) are anabolic hormones that may contribute to increased muscle mass and possibly enhanced athletic performance. Furthermore, the second to fourth digit ratio (2D:4D ratio), suggested as an indirect measurement of prenatal androgen exposure, has been related to athletic ability. LÄS MER