Sökning: "urinary steroid"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden urinary steroid.

  1. 1. Sex steroid metabolism and body composition

    Författare :Charlotte Swanson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :UDP glucuronosyltranferases; polymorphisms; androgens; glucuronidated androgen metabolites; fat mass; bone; metabolic risk factors; population study;

    Sammanfattning : Background: The bioactive androgens testosterone (T) and dihydrotestosterone (DHT) regulate bone and fat mass in men. The effects of androgens are largely determined by the rate of their synthesis and inactivation. LÄS MER

  3. 2. Urinary steroid profiles in doping testing : in relation to natural variation and drug administration

    Författare :Jenny Mullen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : To detect doping with endogenous steroids, such as testosterone, biomarkers in urine are measured. These biomarkers include testosterone and some metabolically related steroids. The measured steroids are combined into ratios and together they make up the steroid profile. LÄS MER

  4. 3. Studies on the extracellular matrix of the dysfunctional pelvic floor

    Författare :Marie Westergren Söderberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Pelvic floor; pelvic organ prolapse; stress urinary incontinence; extracellular matrix; collagen; SLRPs; decorin; lumican; fibromodulin; elastin associated proteins; fibrillin-1; fibulin-5; sex steroid hormone receptors; ER; PR; AR;

    Sammanfattning : Objective: Pelvic floor dysfunction cause impaired quality of life of many women and is one of the most common reasons for gynaecological surgery on benign indications. Little is known about the pelvic floor extracellular matrix as a pre-requisite for mechanical sustainability through vaginal delivery, age and hormonal changes. LÄS MER

  5. 4. Genetics of androgen disposition : Implications for doping tests

    Författare :Jenny Jakobsson Schulze; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Anabolic androgenic steroids (AAS) are derivatives of testosterone. Doping with AAS is a severe challenge to the vision, moral and ethics in sports and has also become an increasing problem in society. Testosterone abuse is conventionally assessed by the urinary testosterone glucuronide/ epitestosterone glucuronide (T/E) ratio, levels above 4. LÄS MER

  7. 5. Steroids and bile acids in intrahepatic cholestasis of pregnancy : effects of treatment with ursodeoxycholic acid

    Författare :Ling-Jie Meng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : A method permitting simultaneous analysis of individual steroid hormone metabolites and bile acids in different forms of conjugation in serum and urine was established. Total bile acids and neutral steroids were extracted from human serum or urine with octadecylsilane-bonded silica, separated into different groups of conjugates by anion-exchange chromatography and analyzed by fast atom bombardment mass spectrometry. LÄS MER