Sökning: "uremic"
Visar resultat 11 - 15 av 51 avhandlingar innehållade ordet uremic.
11. Genetic, molecular and functional analyses of factor I - an inhibitor of the complement system
Sammanfattning : Factor I (FI) is a serine protease that inhibits the complement system by cleaving activated C3 and C4 complement proteins, in the presence of cofactors. Mutations in the gene coding for FI have been identified in complete FI deficient- and atypical hemolytic uremic syndrome (aHUS) patients. LÄS MER
12. Extracellular vesicles in Shiga toxin-mediated disease
Sammanfattning : Extracellular vesicles are released during infectious, inflammatory and prothrombotic conditions. These are membrane-derived vesicles shed by cells during activation, senescence and/or apoptosis. Extracellular vesicles contain and transfer components of the parent cell from which they are shed. LÄS MER
13. Novel in vivo therapeutic approaches to Escherichia coli O157:H7 infection
Sammanfattning : Shiga toxin (Stx), the unique virulence factor released by enterohemorrhagic Escherichia coli (EHEC), associated with gastrointestinal infection and in severe cases hemolytic uremic syndrome (HUS). Up until now, no effective therapies have been developed to control disease progression. LÄS MER
14. Experimental studies of small intestinal permeability and function in uremia
Sammanfattning : The intestinal permeability has been investigated in experimental chronic and acute uremia in rats. The permeability and the mucosal ability to exclude larger molecules have been measured using differently sized polyethylene glycols (PEG 400 and 1000: mean weights of 400 and 1000 dalton, range 326-1162 dalton). LÄS MER
15. Investigation of hepatocyte signaling pathways in chronic kidney disease : clinical and experimental studies
Sammanfattning : Chronic kidney disease (CKD) is defined as a loss of renal function from any cause and lasting for more than three months. The CKD phenotype is similar across multiple etiologies, suggesting that renal damage itself is a dominant factor. LÄS MER