Sökning: "upper motor neuron diseases"

Hittade 5 avhandlingar innehållade orden upper motor neuron diseases.

1. 1. On the Site of the Lesion in Konzo : Clinical and Neurophysiological Studies on a Non-Progressive Upper Motor Neuron Disorder

   Författare :Desire Tshala-Katumbay; Andrew Eisen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Konzo; upper motor neuron diseases; WHO criteria; electroencephalography; evoked potentials; brain involvement; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

   Sammanfattning : Konzo is a permanent spastic para/tetraparesis occurring in undernourished populations in Africa relying on insufficiently processed bitter cassava, which contains cyanogenic compounds, as staple food. Its pathogenetic mechanism is unknown. Our studies aimed at clarifying the lesion in konzo. LÄS MER

3. 2. Metabolomics studies of ALS : a multivariate search for clues about a devastating disease

   Författare :Anna Wuolikainen; Peter M Andersen; Henrik Antti; Stefan L Marklund; Thomas Moritz; Thomas Hankemeier; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyotrophic lateral sclerosis ALS ; motor neuron disease; Lou Gehrig’s disease; human disease; CSF; biomarkers; metabolomics; metabonomics; chemometrics; design of experiments; multivariate analysis.; Neurology; Neurologi; Neurology; neurologi;

   Sammanfattning : Amyotrophic lateral sclerosis (ALS), also known as Charcot’s disease, motor neuron disease (MND) and Lou Gehrig’s disease, is a deadly, adult-onset neurodegenerative disorder characterized by progressive loss of upper and lower motor neurons, resulting in evolving paresis of the linked muscles. ALS is defined by classical features of the disease, but may present as a wide spectrum of phenotypes. LÄS MER

4. 3. Amyotrophic lateral sclerosis and multiple sclerosis associated neuroinflammation : nationwide epidemiological studies on etiology, comorbidities, and treatment

   Författare :Elisa Longinetti; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a relatively rare but fatal neurodegenerative disease characterized by progressive muscle paralysis, due to loss of upper and lower motor neurons. Signs of neuroinflammation have been reported in ALS, however it is still unknown whether neuroinflammation is a cause or a consequence of the motor neuron dysfunction. LÄS MER

5. 4. Immunity and inflammation in amyotrophic lateral sclerosis : an epidemiological approach

   Författare :Can Cui; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a rare but lethal neurodegenerative disease, characterized by degeneration of both upper and lower motor neurons in the brain and spinal cord. The pathogenesis of ALS is, however, not completely clear. LÄS MER

7. 5. Peripheral neuropathy and altered cobalamin metabolism in Parkinson's disease and other movement disorders

   Författare :Mattias Andréasson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Peripheral neuropathy is a disorder of the peripheral nervous system (PNS) that may carry different underlying aetiologies. Studies have suggested PNS involvement may be prevalent in neurological diseases that traditionally have been regarded primarily as disorders of the central nervous system (CNS), including the neurodegenerative disorder Parkinson’s disease (PD). LÄS MER