Sökning: "unknown gene"
Visar resultat 1 - 5 av 533 avhandlingar innehållade orden unknown gene.
1. Myocardial gene therapy and gene expression in angina pectoris
Sammanfattning : Background: Angiogenesis does not fully counteract myocardial ischemia in stable angina pectoris. Refractory angina pectoris, with remaining symptoms despite medication and no possibility for bypass surgery or angioplasty, is rather common. Angiogenic gene therapy is a novel treatment strategy for these patients. LÄS MER
2. Conditional targeting of the PDGF-B gene
Sammanfattning : Platelet derived growth factors (PDGF) are known as mitogens for fibroblasts, smooth muscle cells (SMC) and glia cells in culture. Previous in vivo analyses have shown that PDGF-B is necessary for normal embryonic development and life after birth, but the relative importance of the various cellular sources of PDGF-B during development has not been clarified. LÄS MER
3. Robust inference of gene regulatory networks : System properties, variable selection, subnetworks, and design of experiments
Sammanfattning : In this thesis, inference of biological networks from in vivo data generated by perturbation experiments is considered, i.e. deduction of causal interactions that exist among the observed variables. Knowledge of such regulatory influences is essential in biology. LÄS MER
4. Applied bioinformatics for gene characterization
Sammanfattning : As the vast majority of human protein-encoding genes are now identified, the new challenge placed before life scientists is the determination of the functions of the proteins. Traditionally, intense, directed efforts are applied to decipher the function of a novel protein using laboratory techniques. LÄS MER
5. Exploring Brain Gene Expression i Animal Models of Behaviour
Sammanfattning : The genetic basis for behavioural traits is largely unknown. The overall aim of this thesis was to find genes with importance for behavioural traits related to fear and anxiety. Microarray analysis was used to screen expression profiles of brain regions important for emotional behaviour in dogs, wolves, foxes and mice. LÄS MER