Sökning: "ubiquitin- associated UBA domain"
Hittade 2 avhandlingar innehållade orden ubiquitin- associated UBA domain.
1. Regulation of the ubiquitin-proteasome system : characterization of viral and cellular stabilization signals
Sammanfattning : The ubiquitin-proteasome system plays a fundamental role in virtually every cellular process. Degradation of endogenous proteins by this system is the major source for antigenic peptides that are presented to MHC class I-restricted cytotoxic T cells. LÄS MER
2. To degrade or not to degrade : protein handling by the proteasome
Sammanfattning : The proteasome, a large multi-subunit protease that degrades proteins, must be able to distinguish between substrates deemed for destruction and accessory proteins that should be spared. The shuttle factor Rad23 operates in close proximity to the proteasome in order to deliver proteins for their degradation. LÄS MER