Sökning: "tyrosine hydroxylase"

Visar resultat 21 - 25 av 72 avhandlingar innehållade orden tyrosine hydroxylase.

1. 21. Mucosal regeneration following sinus surgery : an experimental study and clinical study

   Författare :Karin Forsgren; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :chronic sinusitis; histopathology; Caldwell-Luc operation; sinus surgery; rabbit; regeneration; sinus mucosa; experimental sinusitis; microcirculation; blood flow; vasoreactivity; nerve regeneration; sympathetic; neuropeptide Y; tyrosine hydroxylase; immunocytochemistry;

   Sammanfattning : The investigations described in this thesis concerned functional and structural aspects of the regenerated sinus mucosa following sinus surgery. In a biopsy material collected pre- and postoperatively from patients with chronic maxillary sinusitis, randomized for treatment with either Functional Endoscopic Sinus Surgery (FESS) or the Caldwell-Luc procedure (CL), histological parameters were evaluated semi-quantitatively and correlated to endoscopic findings and patients' symptoms. LÄS MER

3. 22. Neurorestorative strategies involving neurogenesis, neuronal precursors and stem cells in animal models of Parkinson's disease

   Författare :Ming Zhao; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Parkinson s disease; substantia nigra pars compacta; adult neurogenesis; stereology; apoptosis; dopamine; tyrosine hydroxylase; nestin; 5-bromodeoxyuridine; [3H]-thymidine; MPTP; 6-OHDA; platelet-derived growth factor-BB;

   Sammanfattning : The general aims of the thesis is to provide evidence for neurogenesis in the adult substantia nigra pars compacta (SNpc), where the dopamine-producing neurons lost in Parkinson's disease (PD) reside; to optimize methods used for detecting newborn nerve cells in adult brain regions with a low rate of neurogenesis; to explore the mechanism of nerve cell death in animal models of parkinsonism and early degenerative and restorative changes in nigral cell populations; and to develop a therapeutic approach that could translate into a future restorative disease-modifying strategy in PD. Paper I. LÄS MER

4. 23. Regulation of signal transduction in the striatum by typical and atypical antipsychotic drugs

   Författare :Kerstin Håkansson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Adenosine A2A receptor; basal ganglia; cAMP-dependent protein kinase; clozapine; DARPP-32; dopamine D 2 receptor; extracellular signal-regulated protein kinases 1 and 2; extrapyramidal side effects; glutamate AMPA receptor; haloperidol; knockout mouse; phosphorylation; schizophrenia; tyrosine hydroxylase.;

   Sammanfattning : The only effective therapy for schizophrenia is based on the use of antipsychotic drugs. These substances act as dopamine D 2 receptor antagonists and can be classified as typical or atypical. Typical antipsychotics, e.g. LÄS MER

5. 24. Regulation of neurotrophins and their receptors : molecular aspects and functional implications

   Författare :Tuija Salin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :neurotrophin; nerve growth factor; brain-derived neurotrophic factor; neurotrophin-3; neurotrophin-4; glia; gliosis; neuron; tyrosine kinase receptor; transgenic; null mutation; gene; exon; intron; mRNA;

   Sammanfattning : The aim of this work was to study the regulation of neurotrophins and their receptors in a functional aspect. The studies included analysis of neuronal and glial neurotrophin gene expression, that was investigated by using molecular biological techniques. LÄS MER

7. 25. Organ-specific autoantibodies in Addison's disease and autoimmune polyendocrine syndrome type I

   Författare :Annika Söderbergh; Uppsala universitet; []
   Nyckelord :Medical sciences; Addison s disease; APS I; Down syndrome; AIRE; autoantibodies; autoantigens; autoimmunity; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

   Sammanfattning : Assessment of autoantibodies is a valuable tool in the diagnostic procedure of autoimmune diseases. The aim of this study was to investigate the prevalence of different autoantibodies and their associations with disease manifestations in patients with Addison's disease and autoimmune polyendocrine syndrome type I (APS I). LÄS MER