Sökning: "two-dimensional gel electrophoresis"

Visar resultat 21 - 25 av 65 avhandlingar innehållade orden two-dimensional gel electrophoresis.

  1. 21. Development of proteomic methods for studying cerebrospinal fluid proteins involved in Alzheimer´s disease

    Författare :Maja Puchades; Göteborgs universitet; []
    Nyckelord :Alzheimer s disease; cerebrospinal fluid; proteomics; mass spectrometry; biomarkers; synaptic proteins; liquid phase IEF; biomarkers;

    Sammanfattning : Alzheimer's disease (AD) is the most common cause of dementia in western countries. The main neuropathological findings in the AD brain are senile plaques, neurofibrillary tangles and degeneration of neurons and synapses. LÄS MER

  3. 22. Chemical and mass spectrometrical methods in protein analysis

    Författare :Madalina Oppermann; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Sensitive analytical methods are essential in protein studies because of frequently encountered limited sample availability. There is a constant need for optimization of sample preparation and analytical procedures for structural characterization of biomedically relevant proteins. Amino acid sequences can be derived from genomic data. LÄS MER

  4. 23. Neuropeptidomics – Expanding Proteomics Downwards

    Författare :Marcus Svensson; Per Andrén; Per Svenningsson; Jonathan Sweedler; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical pharmacology; proteomics; peptidomics; mass spectrometry; neuropeptide; chromatography; Farmaceutisk farmakologi; PHARMACY; FARMACI;

    Sammanfattning : Biological function is mainly carried out by a dynamic population of proteins which may be used as markers for disease diagnosis, prognosis, and as a guide for effective treatment. In analogy to genomics, the study of proteins is called proteomics and it is generally performed by two-dimensional gel electrophoresis and mass spectrometric methods. LÄS MER

  5. 24. Hormone-Sensitive Lipase, new roles for an old enzyme

    Författare :Ola Hansson; diabetes och endokrinologi Genomik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes; Vitamin A; Inflammation; Medicine human and vertebrates ; Medicin människa och djur ; Metabolism; Hormone-Sensitive Lipase; Proteomics; Obesity; White adipose tissue; Skeletal muscle;

    Sammanfattning : Hormone-sensitive lipase (HSL) has a wide tissue distribution with the highest expression found in white adipose tissue (WAT). HSL also has a unique ability to hydrolyze a large panel of substrates including acylglycerols, cholesteryl esters and retinyl esters. HSL is potentially a new drug target for the treatment of obesity and type II diabetes. LÄS MER

  7. 25. Functional Proteome analysis of the molecular mechanism of (myo)fibroblast differentiation

    Författare :Johan Malmström; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fibroblast myofibroblast extracellular matrix asthma COPD PDGF TGF-beta heparan sulfate proteoglycans proteomics mass spectrometry MALDI ESI; Metabolism; Biochemistry; Biokemi; metabolism;

    Sammanfattning : Tissue remodeling is observed in several physiological conditions such as embryogenesis, senescence, wound healing and pregnancy, as well as in several pathological conditions such as fibrosis and tumorgenesis. Fibroblasts play a key role in this tissue remodeling due to their capability of altering the turnover of the extracellular matrix. LÄS MER