Sökning: "tumour marker"

Visar resultat 1 - 5 av 121 avhandlingar innehållade orden tumour marker.

  1. 1. Stromal collagens in colorectal cancer and in colorectal liver metastases : tumour biological implications and a source for novel tumour markers

    Författare :Hanna Nyström; Malin Sund; Peter Naredi; Per Sandström; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; colorectal liver metastases; tumour marker; stroma; type IV collagen; metastatic growth pattern; kirurgi; Surgery;

    Sammanfattning : Background: Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality. About 50 % of patients with CRC will develop subsequent liver metastases (CLM). The survival for untreated CLM is only a few months and liver resection provides the only chance for a lasting cure. LÄS MER

  3. 2. Risk Factors of Tumour Recurrence and Reduced Survival in Rectal Cancer

    Författare :Fredrik Jörgren; Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tumour Marker; Ezrin; Intestinal Perforation; Neoplasm Recurrence; Rectal Neoplasms; Local; Neoplasm Metastasis; Survival Rate; Risk Factors; Surgical; Anastomosis;

    Sammanfattning : In Sweden, 2000 patients are diagnosed with rectal cancer annually. In 1995, the Swedish Rectal Cancer Registry (SRCR) was launched to supervise and assure the quality of the management of rectal cancer. Advances in the management of rectal cancer have reduced the local recurrence (LR) rate and improved survival. LÄS MER

  4. 3. Tumour evolution and novel biomarkers in breast cancer

    Författare :Jana Biermann; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; breast cancer; gene signature; molecular biomarkers; tumour clonality; genomic instability; Swedish haemangioma cohort;

    Sammanfattning : Several gene signatures have been proposed in the past two decades to improve outcome prediction for breast cancer patients and to guide treatment decisions. Current treatment guidelines, however, primarily focus on established clinicopathological features. LÄS MER

  5. 4. Identification, Validation and Implementation of Blastemal Biomarkers in Wilms Tumour

    Författare :Daniel Sehic; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Wilms Tumour; Nephroblastoma; SIX1; Blastema; biomarker; Immunochemisty; Immunohistochemestry;

    Sammanfattning : The aim of this thesis has been to establish biomarkers for the blastemal element in Wilms tumour (WT) – the most common paediatric kidney cancer. Blastema is, together with epithelium and stroma, one of the three common histological elements of WT. WTs dominated by blastema after preoperative chemotherapy are classified as high risk tumours. LÄS MER

  7. 5. Chromosomal Instability and Genomic Amplification in Bone and Soft Tissue Tumours

    Författare :David Gisselsson Nord; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nuclear atypia; kinetochore; anaphase bridge; p53; breakage-fusion-bridge cycle; TP53; HMGIC; MDM2; mitotic instability; genomic instability; FISH; osteosarcoma; liposarcoma; amplification; tumour; chromosome; cytogenetics; Clinical genetics; Klinisk genetik;

    Sammanfattning : Acquired genetic abnormalities are found in all types of malignant tumours and may contribute to neoplastic processes by altering protein structure or dosage. Many bone and soft tissue tumours (BSTT) are characterised by complex patterns of chromosome changes, including extensive intratumour heterogeneity and amplification of DNA sequences. LÄS MER