Sökning: "tumour clonality"
Hittade 5 avhandlingar innehållade orden tumour clonality.
1. Tumour evolution and novel biomarkers in breast cancer
Sammanfattning : Several gene signatures have been proposed in the past two decades to improve outcome prediction for breast cancer patients and to guide treatment decisions. Current treatment guidelines, however, primarily focus on established clinicopathological features. LÄS MER
2. Molecular progression and clonality or urinary bladder cancer
Sammanfattning : The general aim of this work was to investigate the clonality of multifocal bladder tumours, chromosomal deletions and model the initiation-progression of bladder tumours at a molecular level using microsatellite analysis. In a population-based study, we found correlation between stage and grade and the prevalence of loss of heterozygosity (LOH) at all observed chromosome 13 loci and stage and grade, respectively. LÄS MER
3. Detection of immunoglobulin heavy chain gene rearrangement with PCR for MRD analysis in lymphoproliferative disorders
Sammanfattning : Immunoglobulin heavy chain (IGH) gene rearrangement occurs during early B-lymphocyte differentiation, assembling the different IGH gene segments to a functional gene, which can serve as a marker for study of lineage association and detection of Minimal Residual Disease (MRD) in clonal diseases deriving from B-lymphocytes or their early differentiation stages. Use of a molecular marker for the leukemic cells could help improve treatment by monitoring therapeutic efficacy, predicting relapse, and identifying very small amounts of tumour cells contaminating autografts after purging or enrichment of stem cells. LÄS MER
4. Detection and analysis of genetic alterations in normal skin and skin tumours
Sammanfattning : The investigation of genetic alterations in cancer-relatedgenes is useful for research, prognostic and therapeuticpurposes. However, the genetic heterogeneity that often occursduring tumour progression can make correct analysischallenging. LÄS MER
5. T cell antigen receptor usage, phenotype and cytokine production in human diseases
Sammanfattning : T lymphocytes are of critical importance for initiating and controlling immune responses, as the T cell receptor (TCR) for antigen allows a highly specific antigen recognition. Determination of TCR usage and characterization of T cell subsets in different diseases helps us understand the underlying immunopathogenic mechanisms, and may also lead to the development of new therapeutic approaches. LÄS MER