Sökning: "tumor suppressor"

Visar resultat 21 - 25 av 318 avhandlingar innehållade orden tumor suppressor.

  1. 21. Exploring novel roles of tumor pericytes

    Författare :Jong Wook Hong; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Tumor biology has been extensively studied over the last few decades, with a principal focus on how neoplastic cells obtain cellular immortality. A number of oncogenes and tumor suppressor genes have been uncovered that regulate cancerous transformation. LÄS MER

  3. 22. Identification of tumor suppressor genes using the approach of gene inactivation test

    Författare :Fuli Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Epithelial cancers are the most prevalent and lethal diseases in the world. They cause more than 80% of all cancer deaths. Development of these tumors is a complex process involving more than 100 genes from different chromosomes. We know that human chromosome 3 (chr. LÄS MER

  4. 23. Functional studies of the Sro yeast homologues of the Drosophila lethal (2) giant larvae tumor suppressor genes

    Författare :Ingrid Wadskog; Jönköping University; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Ion homeostasis; salt stress; exocytosis; protein targeting; apaptosis; l 2 gl tumour suppressor; S. cerevisiae; SRO7; ENA1; Microbiology; Mikrobiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : .... LÄS MER

  5. 24. Making sense from nonsense and missense : pharmacological rescue of mutant tumor suppressor p53

    Författare :Meiqiongzi Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A large fraction of human tumors carry inactivating mutations in the TP53 tumor suppressor gene. Approximately 75% of these mutations are missense mutations and around 10% are nonsense mutations. TP53 inactivation allows evasion of cell death and rapid tumor progression. LÄS MER

  7. 25. Delection mapping of human 3p in major epithelial types of cancer and fine localization of candidate tumor suppressor genes

    Författare :Jian Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Tumor suppressor gene; epithelial carcinoma; human chromosome 3p;

    Sammanfattning : Allele loss and deletion mapping using microsatellite markers and the detection of homozygous deletions represented until now the most powerful method to localize potential TSGs. Loss of heterozygosity (LOH) involving several chromosome 3p regions accompanied by chromosome 3p deletions are detected in almost 100% of renal cell carcinoma (RCC), small (SCLCs) and more than 90% of non-small (NSCLC) cell lung cancers. LÄS MER