Sökning: "tumor necrosis factor-?"
Visar resultat 1 - 5 av 7 avhandlingar innehållade orden tumor necrosis factor-?.
1. Angiogenesis in childhood malignancies
Sammanfattning : Angiogenesis is necessary for the growth and spread of solid tumors. In these studies angiogenesis was measured in childhood malignancies in general and in Wilms’ tumor in particular, and cutting needle biopsy (CNB) specimens were evaluated for diagnosis in childhood renal tumors. LÄS MER
2. Experimental autoimmune sialadenitis : studies of immunopathogenesis, cellular signaling and MHC genetics
Sammanfattning : Experimental autoimmune sialadenitis (EAS), an animal model for Sjogren´s syndrome (SS) in humans, develops spontaneously in certain mouse strains. A major feature of EAS and SS is infiltration of exocrine glands by mononuclear cells (MNC), and functional impairment of predominantly salivary and lachrymal glands leading to mouth and eye dryness. LÄS MER
3. Molecular Mechanisms in Endothelial Cell Differentiation
Sammanfattning : Angiogenesis is the formation of new blood vessels from the pre-existing blood vessels. Blood vessels are composed of endothelial cells and supporting musculature. Angiogenesis is regulated by numerous soluble ligands and by cell-matrix interactions. LÄS MER
4. Rho-GTPases in Rheumatoid Arthritis
Sammanfattning : The success of alleviating rheumatoid arthritis (RA) symptoms is complicated by both heterogeneity of the disease and lack of predictive markers to guide treatment options. Deregulated Rho-GTPases, a family of hydrolase enzymes catalyzing guanosine triphospate (GTP) to guanosine diphospate (GDP), have a detrimental role in many diseases including RA. LÄS MER
5. Studies of pathophysiological mechanisms and oral cavity manifestations in chronic inflammatory diseases
Sammanfattning : Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease with a 9:1 female predominance where many genetic and clinical characteristics overlap with other inflammatory conditions such as rheumatoid arthritis (RA). Closely monitoring and treating active disease leads to better prognosis and quality of life for these patients since a cure is to date not available. LÄS MER