Sökning: "tumor necrosis factor a"
Visar resultat 11 - 15 av 215 avhandlingar innehållade orden tumor necrosis factor a.
11. Tumor necrosis factor superfamily members CD137 and OX40 ligand in vascular inflammation
Sammanfattning : Atherosclerosis, an inflammatory disease, is the major cause of cardiovascular disease - the main cause of death worldwide. T cells are central orchestrators of inflammation in atherosclerosis and critically depend on costimulation for adequate function. LÄS MER
12. Prognostic factors in soft tissue sarcoma. Tissue microarray for immunostaining, the importance of whole-tumor sections and time-dependence
Sammanfattning : In adult soft tissue sarcoma (STS) of the extremities and trunk wall, improved prognostic factors are needed to identify patients at high-risk for metastasis. Various factors are included in the many prognostic systems currently in use and the prognostic value of immunohistochemical (IHC) expression of biological markers is unclear. LÄS MER
13. Regional fluxes of tissue plasminogen activator in porcine endotoxemia
Sammanfattning : Formation of fibrin clots in the microcirculation during severe sepsis contributes to organ failure, frequently involving the lungs and the splanchnic organs. Tissue type plasminogen activator, tPA, is the key activator of intravascular fibrinolysis with plasminogen activator inhibitor type-1, PAI-1, as its main inhibitor. LÄS MER
14. Hematopoietic stem cells: c-mpl and TNF receptor function
Sammanfattning : Hematopoietic stem cells (HSC) are crucial to life. Daily and throughout the life span of an individual they are responsible for replacing approximately 10(12) mature blood cells. Mature cells are, for example, required for transportation of oxygen, defense against infections and to stop bleeding. LÄS MER
15. Early Blood Cell Formation "in sickness and health, ´till death do us part"
Sammanfattning : Hematopoietic stem cells (HSC), the ancestors of all blood cells, have the ability to give rise to mature effector cells through a series of developmental steps. This is a tightly regulated, though a highly dynamic process: on the one hand, dysregulation in steady-state could lead to under- or overgrowth of certain blood cell lineages, whereas, on the other hand, demands for certain mature blood cells can change dramatically in cases like bleeding and infections. LÄS MER