Sökning: "tumor hypoxia"
Visar resultat 1 - 5 av 91 avhandlingar innehållade orden tumor hypoxia.
1. Imaging the tumor microenvironment : the dynamics and modification of hypoxia
Sammanfattning : The tumor vasculature is poor and heterogeneous which may result in inadequate oxygenation and changed energy status. In addition the balance between cell proliferation and the rate of cell death is disturbed, which results in tumor growth. LÄS MER
2. Hypoxia-Inducible Factors in Tumor Cell Differentiation and Tumor Vascularization
Sammanfattning : Mammalian cells, including tumor cells, adapt to hypoxia via stabilization of two transcription factors - Hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha. Among other consequences, hypoxia is a main driving force behind angiogenesis. LÄS MER
3. Stromal and tumor cell responses to hypoxia and treatment within the glioma microenvironment
Sammanfattning : Glioblastoma is the most aggressive primary brain tumor in adults. Despite treatment, tumors invariably recur, and the recurring tumor is resistant to therapies. New approaches are needed for the successful treatment of glioblastoma patients.Tumors are not simply a compilation of molecularly and phenotypically identical neoplastic cells. LÄS MER
4. MOLECULAR ASPECTS OF ENDOTHELIAL CELL FUNCTION AND HYPOXIA-DEPENDENT TUMOR ANGIOGENESIS
Sammanfattning : Hypoxia, or deficient oxygen levels, is an inherent feature of rapidly expanding tumor tissue. In order to survive in the hostile, hypoxic environment and to restore the supply of oxygen and nutrients tumor cells activate a variety of adaptive mechanisms. Among them, hypoxia-induced angiogenesis, i.e. LÄS MER
5. Transcriptional Regulation by Hypoxia-Inducible Factors in Tumor Cells
Sammanfattning : Cancer is a major cause of human morbidity and mortality, and the risk of developing cancer is about one in three life times. Neuroblastoma is the most common extra-cranial solid tumor among children and arises from early sympathetic nervous system (SNS) cells arrested in their development. LÄS MER