Sökning: "tumor evolution"
Visar resultat 1 - 5 av 50 avhandlingar innehållade orden tumor evolution.
1. Cancer Evolution under Chemotherapy Treatment
Sammanfattning : Background: Chemotherapy resistance is a critical issue in oncology, being responsible for the majority of deaths in modern cancer care. My PhD work has focused on two cancer types where such drug resistance is a major clinical issue: epithelial ovarian cancer (EOC) and Wilms tumor (WT). LÄS MER
2. Inter and intra-tumor models of somatic evolution in cancer
Sammanfattning : Cancer is a disease caused by the accumulation of somatic mutations in an evolutionary process. Mutations in so-called cancer driver genes provide the harboring cells with particular selective advantages and result in cancer progression. LÄS MER
3. Massively Parallel Sequencing of Gene Fusion-Associated Sarcomas
Sammanfattning : .... LÄS MER
4. Affibody molecules targeting the epidermal growth factor receptor for tumor imaging applications
Sammanfattning : Tumor targeting and molecular imaging of protein markers specific for or overexpressed in tumors can add useful information in deciding upon treatment and assessing the response to treatment for a cancer patient. The epidermal growth factor receptor (EGFR) is one such tumor-associated receptor, which expression is abnormal or upregulated in various cancers and associated with a poor patient prognosis. LÄS MER
5. Staphylococcal surface display in directed evolution
Sammanfattning : Engineered affinity proteins have together with naturally derived antibodies becomeindispensable tools in many areas of life-science and with the increasing number ofapplications, the need for high-throughput methods for generation of such different affinityproteins is evident. Today, combinatorial protein engineering is the most successful strategy toisolate novel non-immunoglobulin affinity proteins. LÄS MER