Sökning: "tumör"

Visar resultat 1 - 5 av 142 avhandlingar innehållade ordet tumör.

1. 1. Hepatic and Peritoneal Colorectal Metastases : Aspects of Prognosis and Treatment

   Författare :Haile Mahteme; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Colorectal cancer; lever metastas; peritoneal metastas; intraperitoneal; tumör reduktion; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

   Sammanfattning : Although two-thirds of colorectal cancer patients are cured by surgery, approximately 50% of the patients with this disease develop locally recurrent or distant metastases during the course of their illness. The aim of this study was to identify metastatic sites associated with poor prognosis in rectal cancer and then to investigate methods that can prevent the development and growth of metastases and optimise uptake of drugs at these sites in animal models. LÄS MER

3. 2. Targeting the prostate tumor microenvironment and vasculature : the role of castration, tumor-associated macrophages and pigment epithelium-derived factor

   Författare :Sofia Halin; Anders Bergh; Pernilla Wikström; Stina Rudolfsson; Carl-Henrik Heldin; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; angiogenesis; castration therapy; microenvironment; stroma; tumor-associated macrophages; pigment epithelium-derived factor; PEDF; vasculature; Pathology; Patologi; patologi; Pathology;

   Sammanfattning : BACKGROUND: Prostate cancer is the most common cancer among Swedish men. For patients with metastatic prostate cancer the standard therapy is castration, a treatment that initially provides symptomatic relief but unfortunately is not curative. New therapeutic targets for advanced prostate cancer are therefore needed. LÄS MER

4. 3. The role of stroma-derived substances in breast cancer progression and their function as tumour markers

   Författare :Malin Jansson; Malin Sund; Daniel Öhlund; Ola Billing; Emma Niméus; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; perlecan; type IV collagen; type I collagen; extracellular matrix; tumour biomarkers; Surgery; kirurgi;

   Sammanfattning : Background: In 2020, more than 2,260,000 women were diagnosed with breast cancer. Most patients are cured with surgery and adjuvant treatment, but despite that, approximately 700,000 women die of the disease every year. The historical focus on breast cancer progression has been on the malignant epithelial cell. LÄS MER

5. 4. Identification, Validation and Implementation of Blastemal Biomarkers in Wilms Tumour

   Författare :Daniel Sehic; Avdelningen för klinisk genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Wilms Tumour; Nephroblastoma; SIX1; Blastema; biomarker; Immunochemisty; Immunohistochemestry;

   Sammanfattning : The aim of this thesis has been to establish biomarkers for the blastemal element in Wilms tumour (WT) – the most common paediatric kidney cancer. Blastema is, together with epithelium and stroma, one of the three common histological elements of WT. WTs dominated by blastema after preoperative chemotherapy are classified as high risk tumours. LÄS MER

7. 5. Impact of Lysosomal Function in Cancer and Apoptosis

   Författare :Cathrine Nilsson; Karin Öllinger; Emmanuelle Liaudet-Coopman; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Onkologi;

   Sammanfattning : Lysosomes, the recycling units of the cell, participate in the signaling pathway to apoptosis, which has stimulated the search for anti-cancer drugs targeting the lysosomal compartment. Lysosomes are, however, often altered in cancer cells. LÄS MER