Sökning: "trnascription"

Hittade 1 avhandling innehållade ordet trnascription.

1. 1. Gene regulation mechanisms by the transcriptional coregulator mastermind-like 1

   Författare :Mariana Saint Just Ribeiro; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Acetylation autoacetylation; chromatin; trnascription; coregulator; Mastermind-like 1 MAML1 ; p300; Notch signaling; phosphorylation; GSK3beta;

   Sammanfattning : MAML1 was first identified as a coactivator for Notch receptors, but later it was also found to function as a coactivator for several other activators, including p53, beta-catenin, and MEF2C. MAML1 is critical for Notch signalling and has been shown to act cooperatively with the histone acetyltransferase (HAT) p300 in transcription that is mediated by the Notch intracellular domain (Notch IC). LÄS MER