Sökning: "trimethylamine N-oxide TMAO"

Hittade 4 avhandlingar innehållade orden trimethylamine N-oxide TMAO.

  1. 1. Polyphenols in Swedish berries and pulses : Characterization and in vivo effects of fractions from lingonberries and brown beans in an Apoe-/- mouse model

    Författare :Jiyun Liu; Cornelia Witthöft; Anne-Maria Pajari; Linnéuniversitetet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; lingonberry; brown bean; flavonoids; phenolic acids; dietary fiber; HPLC-UV MS; atherosclerotic plaque; plasma lipid; gut microbiota; short-chain fatty acids; trimethylamine N-oxide; Apoe- - mice; lingon; bruna bönor; flavonoider; fenolsyror; kostfiber; HPLCUV MS; aterosklerotisk plaketter; plasmalipid; tarm-mikrobiota; kortkedjiga fettsyror; trimetylamin N-oxid; Apoe- - möss; Livsmedelsvetenskap; Food Science;

    Sammanfattning : Consumption of berries and pulses can protect against atherosclerosis and other metabolic diseases, by modulating plasma lipid profile, gut microbiota, and microbiota-dependent metabolites. These nutritional benefits are often attributed to high content of polyphenols (flavonoids and phenolic acids) and dietary fiber. LÄS MER

  3. 2. Disease-causing Keratin Mutations and Cytoskeletal Dysfunction in Human Skin : In vitro Models and new Pharmacologic Strategies for Treating Epidermolytic Genodermatoses

    Författare :Jean Christopher Chamcheu; Anders Vahlquist; Hans Törmä; Harshad Navsaria; Marie Virtanen; Torbjörn Egelrud; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epidermolysis bullosa simplex; epidermolytic ichthyosis; genodermatoses; keratin; keratin mutation; keratinocytes; gene therapy; pharmacological therapy; immortalization; gene regulation; trimethylamine N-oxide TMAO ; sodium 4-phenylbutyrate 4-PBA ; tissue engineering; cell culture; heat shock proteins; MAP kinases; Dermatology and venerology; Dermatologi och venerologi; Dermatologi och venereologi; Dermatology and Venerology;

    Sammanfattning : Epidermolysis bullosa simplex (EBS) and epidermolytic ichthyosis (EI) are rare skin fragility diseases characterized by intra-epidermal blistering due to autosomal dominant-negative mutations in basal (KRT5 or KRT14) and suprabasal (KRT1 or KRT10) keratin genes,  respectively. Despite vast knowledge in the disease pathogenesis, the pathomechanisms are not fully understood, and no effective remedies exist. LÄS MER

  4. 3. Methods for the Synthesis of PET Tracers and NMR Studies of Ribonuclease A

    Författare :Linda Samuelsson; Bengt Långström; Sharon Stone-Elander; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; [11C]methyl iodide; Stille reaction; palladium; Ribonuclease A; osmolytes; PFG-NMR; Organisk kemi; Organic chemistry; Organisk kemi;

    Sammanfattning : This thesis contains two parts.In the first part, general and versatile palladium-mediated 11C-C bond forming reactions for use in the production of radiotracers for Positron Emission Tomography (PET) were explored. LÄS MER

  5. 4. Chronic kidney disease and early vascular ageing : pinpointing culprits of injury and targets for intervention

    Författare :Sam Hobson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic kidney disease (CKD) is a progressive non-communicable disease, and a clinical model of premature ageing. Approximately 1 in 10 people globally have CKD, defined as abnormalities of kidney structure and/or function that persist for more than threemonths. LÄS MER