Sökning: "traumatic brain injury Anaesthesiology glucose glycerol lipolysis epidural postoperative analgesia experimental pancreatitis human blood-brain barrier morphine pharmacokinetics Microdialysis intensive care intensive care Anestesiologi intensivvård"

Hittade 1 avhandling innehållade orden traumatic brain injury Anaesthesiology glucose glycerol lipolysis epidural postoperative analgesia experimental pancreatitis human blood-brain barrier morphine pharmacokinetics Microdialysis intensive care intensive care Anestesiologi intensivvård.

  1. 1. Microdialysis and Intensive Care. Clinical and experimental studies

    Författare :Per Ederoth; Anestesiologi och intensivvård; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaesthesiology; traumatic brain injury; glucose; glycerol; lipolysis; epidural; postoperative analgesia; experimental pancreatitis; human; blood-brain barrier; morphine; pharmacokinetics; Microdialysis; intensive care; Anestesiologi; intensivvård;

    Sammanfattning : Microdialysis was used to monitor local concentrations of energy metabolites in different organs, and to study the pharmacokinetics of morphine over the blood-brain barrier in intact and injured brain tissue in conditions treated in the Intensive Care Unit. After major abdominal or thoracoabdominal surgery, postoperative thoracic epidural analgesia resulted in higher glycerol concentrations in the deltoid subcutaneous adipose tissue, implying increased lipolysis, on the third postoperative day as compared to intravenous infusion of morphine, possibly due to a locally increased sympathetic tone. LÄS MER