Sökning: "translation bacteria"

Visar resultat 1 - 5 av 52 avhandlingar innehållade orden translation bacteria.

  1. 1. Adaptive Evolution of the Bacterial Translation Machinery

    Författare :Arindam De Tarafder; Suparna Sanyal; Michael Y. Pavlov; Ruben L. Jr. Gonzalez; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ribosome; Translation; Translation machinery; Elongation; Evolution; RNA world; Cold bacteria; Molekylär biovetenskap; Molecular Life Sciences;

    Sammanfattning : The process of protein synthesis via translation is of paramount importance for the existence of life on Earth. The bacterial translation machinery has embraced more than 3.5 billion years of molecular evolution to adapt and function efficiently under the provided physiological conditions. LÄS MER

  3. 2. Tracking single molecules in uncharted territory : A single-molecule method to study kinetics in live bacteria

    Författare :Javier Aguirre Rivera; Magnus Johansson; Dmitri N. Ermolenko; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; single-molecule; protein synthesis; fluorescence microscopy; antibiotics; aminoglycosides; macrolides; apramycin; gentamicin; paromomycin; S13; translation; bacteria; Molekylär biovetenskap; Molecular Life Sciences;

    Sammanfattning : The synthesis of proteins, also known as translation, is a fundamental process in every living organism. The steps in the translation of genetic information to functional proteins have been meticulously studied, mostly using in vitro techniques, yielding a detailed model of their mechanisms. LÄS MER

  4. 3. Ribosome standby sites and other structural aspects of translation initiation regions in Escherichia coli

    Författare :Maaike M. Sterk; Gerhart E. H. Wagner; Fredrik Söderbom; Isabella Moll; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ribosome standby sites; translation initiation; mRNA structure; bacteria;

    Sammanfattning : Translation initiation, which is rate-limiting in protein synthesis, is often the step at which regulation occurs. Here, we investigated several mechanisms of translation initiation in Escherichia coli, including their control. LÄS MER

  5. 4. Evolutionary Mechanisms Shaping Bacterial Translation Termination

    Författare :Shreya Pundir; Suparna Sanyal; Martin Ott; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Ribosome; Protein; Release Factor; Translation; Termination; Stop codon; Evolution; Mutation; Kinetics; Cryo-EM; Molekylär biovetenskap; Molecular Life Sciences;

    Sammanfattning : Translation termination in bacteria involves precise reading of stop codons (UAA, UAG, UGA) and coordinated peptidyl-tRNA hydrolysis by the class-I release factors (RFs) on the ribosome (70S). This thesis investigates the evolutionary and post-translational modification mechanisms of these RFs and the concurrent effect on bacterial translation termination. LÄS MER

  7. 5. Dynamic Organization of Molecular Machines in Bacteria

    Författare :Bhupender Singh; Santanu Dasgupta; Leif A. Kirsebom; Don G. Ennis; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; molecular machines; bacteria; cell cycle; ribosome; replisome; divisome; spore; E. coli; H. pylori; Mycobacteria; Microbiology; Mikrobiologi; Mikrobiologi; Microbiology;

    Sammanfattning : Bacterial cells were once treated as membrane-enclosed bags of cytoplasm: a homogeneous, undifferentiated suspension in which polymers (proteins, nucleic acids, etc.) and small molecules diffused freely to interact with each other. LÄS MER