Sökning: "transforming growth factor"

Visar resultat 6 - 10 av 172 avhandlingar innehållade orden transforming growth factor.

1. 6. Transforming growth factor-ß. Signal regulation in health and disease

   Författare :Urban Molander; Göteborgs universitet; []
   Nyckelord :TGF-b; BMP; Smad; signal transduction; LDL; skin tumour; mesangial;

   Sammanfattning : TGF-b superfamily members have been shown to play a pivotal role in multicellular organisms. Knowledge about signal transduction pathways is important in order to understand and cure diseases like cancer where TGF-b´s growth inhibitory signal often are disenabled via mutated or absent signalling components. LÄS MER

3. 7. The role of transforming growth factor‐β signaling and hypoxia‐inducible factors in renal cell carcinoma

   Författare :Pramod Mallikarjuna; Maréne Landström; Börje Ljungberg; Raviprakash Tumkur Sitaram; Anders Bjartell; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-β; Hypoxia; Renal cell carcinoma; ccRCC; non-ccRCC; transforming growth factor-β; ALK5; pVHL; HIF-α; SNAIL1; molekylärbiologi; Molecular Biology;

   Sammanfattning : Renal cell carcinoma (RCC) is the cancer of the kidneys; about 1100 patients with RCC are diagnosed in Sweden each year. RCC can be classified into several subtypes, clear cell renal cell carcinoma (ccRCC) is most common accounting to about 70% of all RCCs, and also the most lethal; papillary renal cell carcinoma (pRCC) accounts to about 10%‐15%, while chromophobe renal cell carcinoma (chRCC) accounts to about 5% of all RCCs. LÄS MER

4. 8. Growth factor regulation of the urokinase plasminogen activator (uPA) system in human endometrium, and the significance of uPA receptor activation in endometrial angiogenesis

   Författare :Tove Sandberg; Lund Obstetrik och gynekologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstetrics; endothelial cell migration; angiogenesis; uPA:PAI-1 complex; uPAR; TGF-beta; PAI-1; EGF; uPA; Growth factor; gynaecology; andrology; reproduction; sexuality; Obstetrik; gynekologi; andrologi; reproduktion; sexualitet;

   Sammanfattning : The purpose of this thesis was to examine the role of growth factors and the urokinase plasminogen activator (uPA) system in human endometrial angiogenesis. Growth factors as well as progesterone increased expression of the main inhibitor of uPA (PAI-1) in primary cultures of endometrial stromal cells. LÄS MER

5. 9. Platelet-derived growth factor-induced signal transduction

   Författare :Sigrídur Valgeirsdóttir; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cellbiologi; Cell biology; Cellbiologi; molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : Platelet-derived growth factor (PDGF), a potent mitogen for mesenchymal cells, elicits its effects by binding to cell surface tyrosine kinase receptors, denoted α- and β-receptors. This thesis describes the mechanism of interaction between stimulated PDGF receptors and various intracellular molecules. LÄS MER

7. 10. Posterior capsule opacification : An experimental study in vitro and in vivo

   Författare :Niklas Wallentin; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Posterior capsule opacification PCO ; after-cataract; lens epithelial cell; proliferation; aqueous humor AqH ; inflammation; growth factors; basic fibroblast growth factor bFGF ; transforming growth factor-β TGF-β ; extracapsular cataract extraction; corneal incision; rabbit; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; galenisk farmaci; Pharmaceutics;

   Sammanfattning : The clinical and economic significance of posterior capsule opacification (PCO) makes it an important public health problem. A better understanding of the pathogenesis in order to reduce/prevent PCO is needed. For this purpose an experimental model in the rabbit was used and further developed in thisthesis. LÄS MER