Sökning: "transdermal"

Visar resultat 1 - 5 av 24 avhandlingar innehållade ordet transdermal.

  1. 1. A Fully Integrated Microneedle-based Transdermal Drug Delivery System

    Författare :Niclas Roxhed; Göran Stemme; Mark G. Allen; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microneedle; Transdermal; Intradermal; Drug delivery; DRIE; MEMS; Microsystem; Medical technology; Medicinsk teknik;

    Sammanfattning : Patch-based transdermal drug delivery offers a convenient way to administer drugs without the drawbacks of standard hypodermic injections relating to issues such as patient acceptability and injection safety. However, conventional transdermal drug delivery is limited to therapeutics where the drug can diffuse across the skin barrier. LÄS MER

  3. 2. Sampling from a suction induced mini-erosion in human skin. Methodological studies

    Författare :Christer Svedman; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vascular permeability; neurogenic inflammation; glucose; diabetes mellitus; interstitial fluid; transdermal; skin; sampling; Medicine human and vertebrates ; Medicin människa och djur ;

    Sammanfattning : Dermal interstitial fluid (IF) was extracted serially and painlessly by brief suction for as long as 6 days. The erosion was otherwise kept occluded, Sample volumes exceded those required for measuring a wide range of biological substances. Epidermal regeneration was rapid. LÄS MER

  4. 3. Electrochemical Methods for Drug Characterisation and Transdermal Delivery : Capillary Zone Electrophoresis, Conductometry, and Iontophoresis

    Författare :Nadia Merclin; Per Hansson; Sven Engström; Arto Urtti; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Capillary zone electrophoresis; precision conductometry; iontophoresis; passive diffusion; lidocaine; ALA; ALA-ester derivatives; sponge phase; carbopol gel; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Sammanfattning : This thesis concerns the development and utilisation of techniques for characterisation and transdermal delivery of various systems for pharmaceutical applications.The degree of dissociation of drug molecules and the mobilities of the different species formed are essential factors affecting the rate of drug delivery by iontophoresis. LÄS MER

  5. 4. Assessment of microvascular function by use of transdermal iontophoresis : methodological aspects

    Författare :Erik Droog Tesselaar; Folke Sjöberg; Angela Shore; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Iontophoresis; Microcirculation; Laser-Doppler; Acetylcholine; Sodium nitroprusside; Pharmacodynamics; Pharmacokinetics skin; Physiology and pharmacology; Fysiologi och farmakologi;

    Sammanfattning : Assessment of the microcirculation is of major importance in understanding the physiology of the vasculature and in assessing te vascular effects of pathological conditions such as diabetes, hypertension and sepsis. Transdermal iontophoresis can be used to non‐invasively introduce vasoactive drugs into the skin. LÄS MER

  7. 5. Ceramic Materials for Administration of Potent Drugs

    Författare :Bing Cai; Susanne Bredenberg; Håkan Engqvist; Wei Xia; Miguel Manzano García; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Tamper-resistance; Oral formulation; Transdermal formulation; Biomaterials; Microneedles;

    Sammanfattning : This thesis aimed to investigate and document the potential of applying ceramics in two specific drug delivery applications: tamper-resistant opioid formulations and transdermal enhancement protrusions.Geopolymers were developed into the matrix for a tamper-resistant formulation, aiming to protect drug substances from non-medical abuse. LÄS MER