Sökning: "transcriptional regulation"

Visar resultat 21 - 25 av 768 avhandlingar innehållade orden transcriptional regulation.

1. 21. Unravelling Mechanistic Insights of Eukaryotic Transcriptional Control

   Författare :Johanna Hörberg; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Transcriptional control; Gene expression regulation; DNA supercoiling; DNA methylation; DNA-protein recognition; Basic-Leucine-Zipper transcription factors; Basic-Helix-Loop-Helix transcription factors; Sequence specific DNA plasticity; Transcription factor cooperativity; Cancer; Molecular modelling; Molecular dynamics;

   Sammanfattning : DNA transcription involves the association of multiple proteins with DNA to convert the genetic information into messenger-RNA transcripts, which later will be translated into proteins. Con-trolled regulation of transcription is imperative for preserving the healthy and homeostatic state of cells. LÄS MER

3. 22. Transcriptional regulation of the Epstein-Barr virus nuclear antigen 1 gene in latent and lytic stages of infection

   Författare :Henrik Zetterberg; Göteborgs universitet; []
   Nyckelord :Epstein-Barr virus; EBNA1; Burkitt s lymphoma; nasopharyngeal carcinoma; ; B-lymphocyte; transformation; transcriptional regulation;

   Sammanfattning : Epstein-Barr virus (EBV) is a lymphotropic herpesvirus that infects more than 90% of humans worldwide. The virus is the causative agent of infectious mononucleosis, a self-limiting lymphoproliferative disorder, and is also associated with a variety of malignancies including Burkitt's lymphoma (BL), Hodgkin's disease (HD), nasopharyngeal carcinoma (NPC), and lymphoproliferative disorders in immunocompromised individuals. LÄS MER

4. 23. Tripeptidyl-Peptidase II : Structure, Function and Gene Regulation

   Författare :Ann-Christin Lindås; Birgitta Tomkinson; Mikael Widersten; Ralf Morgenstern; Uppsala universitet; []
   Nyckelord :Biochemistry; gene regulation; protein expression; enzyme kinetics; tripeptidyl-peptidase II; proteasome; intracellular protein degradation; exopeptidase; Biokemi;

   Sammanfattning : The protein degradation process is of vital importance for the cell to maintain cellular functions. An important enzyme in this process is the multimeric tripeptidyl-peptidase II (TPP II). It removes tripeptides from a free N-terminus of the substrates. LÄS MER

5. 24. A Bioinformatics Study of Human Transcriptional Regulation

   Författare :Adam Ameur; Jan Komorowski; Claes Wadelius; Philipp Bucher; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; microarray; ChIP-chip; ChIP-seq; transcription factor; histone modification; motif search; Bioinformatics; Bioinformatik;

   Sammanfattning : Regulation of transcription is a central mechanism in all living cells that now can be investigated with high-throughput technologies. Data produced from such experiments give new insights to how transcription factors (TFs) coordinate the gene transcription and thereby regulate the amounts of proteins produced. LÄS MER

7. 25. Transcriptional regulation of neural development and degeneration

   Författare :Giulia Gaudenzi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The architecture and functional interactions of the cerebral cortex are fascinating in their complexity of billions of neurons and glial cells connected in intricate circuitries and spatial regions. During development, transcription factors and chromatin modifiers work together to coordinate gene expression programs that drive the formation of the cerebral cortex. LÄS MER