Sökning: "transcript profiling"

Visar resultat 21 - 25 av 37 avhandlingar innehållade orden transcript profiling.

  1. 21. Molecular dissection of Bruton’s tyrosine kinase signaling in hematopoietic cells using RNAi

    Författare :Juhana E Heinonen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : RNA mediated gene silencing, RNA interference (RNAi), has recently been identified in mammalians. This thesis describes the utilization and development of RNAi based tools for signal transduction research. The effects of Bruton s tyrosine kinase (Btk) down-regulation with RNAi have been studied with gene expression profiling in hematopoietic cells. LÄS MER

  3. 22. Circulating platelets : a novel liquid biopsy source for cancer diagnostics and therapy stratification

    Författare :Lee-Ann Tjon-Kon-Fat; Jonas Nilsson; Pernilla Wikström; Michiel Pegtel; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; platelets; biomarkers; liquid biopsy; therapy stratification; personalised medicine; Prostate cancer;

    Sammanfattning : As conventional tissue biopsies have several drawbacks, much effort has been directed toward the development of minimal-invasive liquid biopsy platforms for detecting and profiling cancer.Platelets are the second most abundant cells in blood and have very versatile functions both in physiological and pathophysiological conditions. LÄS MER

  4. 23. Characterisation of molecular alterations in diffuse large b-cell lymphoma with respect to transformation, progression and prognostic markers

    Författare :Anna Kwiecińska; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma type, and comprises nearly 500 newly diagnosed cases in Sweden every year. DLBCL is a group of aggressive lymphomas that are extremely heterogeneous and differ in morphology, immunophenotype, molecular and clinical features as well as in response to therapy. LÄS MER

  5. 24. Induced defence responses in Picea abies triggered by Heterobasidion annosum s.l

    Författare :Jenny Arnerup Christiansson; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Norway spruce [Picea abies (L.)Karst.] is a key tree species for forest industry in Europe and stem and butt rot caused by Heterobasidion parviporum (Fr.) Niemelä & Korhonen is one of its major disease problems. LÄS MER

  7. 25. Metabolomics and wood development : catching a metabolome

    Författare :Annika Johansson; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The tree industry is one of Sweden's most important economic sectors, producing pulp, paper, wooden goods and wood as a bioenergy source. Understanding the biology behind the processes of tree growth and wood development is a key to maximizing the use of wood as raw material. LÄS MER