Sökning: "transaminase"

Visar resultat 6 - 10 av 23 avhandlingar innehållade ordet transaminase.

  1. 6. Amine transaminase: Process development aspects for chiral amine synthesis

    Författare :Tim Börner; Bioteknik; []
    Nyckelord :;

    Sammanfattning : Many modern drugs contain chiral amine moieties and the need for more efficient processes to synthesize these amines in high optical purity and concentration are greatly demanded by the fine chemical and pharma industry. Amine transaminases (ATA) allow for the direct asymmetric synthesis of optically pure amines from ketone substrates. LÄS MER

  3. 7. Amine Transaminases in Biocatalytic Amine Synthesis

    Författare :Henrik Land; Per Berglund; Helen C. Hailes; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Amine Transaminase; Biocatalysis; Transamination; Reductive Amination; Enzyme; Enzyme Engineering; Equilibrium Displacement; Screening; Enzyme Stability; Bioteknologi; Biotechnology;

    Sammanfattning : The use of enzymes, nature´s own catalysts, both isolated or as whole cells to perform chemical transformations is called biocatalysis. As a complement to classical chemical catalysis, biocatalysis can be an environmentally friendly and more economical option in the production and synthesis of chemicals. LÄS MER

  4. 8. Stability and inactivation mechanisms of two transaminases

    Författare :Shan Chen; Per Berglund; Patrick Adlercreutz; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Amine Transaminase; Operational Stability; Inactivation Pathway; Enzyme Unfolding; Phosphate Group Binding Cup; Bioteknologi; Biotechnology;

    Sammanfattning : In the past decades, more and more enzymes are employed as biocatalysts in industrial processes because of their advantages, such as high efficiency, substrate selectivity and stereoselectivity. Among them, amine transaminases (ATAs) are pyridoxal 5’-phosphate (PLP) dependent enzymes. LÄS MER

  5. 9. Quantum Chemical Studies of Enzymatic Reaction Mechanisms

    Författare :Bianca Manta; Fahmi Himo; Lubomir Rulisek; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; density functional theory; B3LYP; enzyme; cluster approach; mechanism; zinc; manganese; cytosine deaminase; ω-transaminase; dinitrogenase reductase-activating glycohydrolase; dual substrate recognition; organisk kemi; Organic Chemistry;

    Sammanfattning : Computer modeling of enzymes is a valuable complement to experiments. Quantum chemical studies of enzymatic reactions can provide a detailed description of the reaction mechanism and elucidate the roles of various residues in the active site. LÄS MER

  7. 10. ω-Transaminase Catalyzed Synthesis of Chiral Amines - Process Improvements Through Whole-cell Immobilization and in situ Product Removal

    Författare :Gustav Rehn; Bioteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Sammanfattning : The industrial use of biocatalysts is increasingly important in the production of e.g. pharmaceuticals, chemicals, fuels and foodstuffs. A successful biocatalytic process is dependent on many factors, such as the biocatalyst properties, the nature of the reaction, reactor type and downstream processing. LÄS MER