Sökning: "toxin-antitoxin systems"

Hittade 5 avhandlingar innehållade orden toxin-antitoxin systems.

1. 1. Bioinformatics, evolution and revolution in our understanding of toxin-antitoxin systems

   Författare :Chayan Kumar Saha; Gemma C. Atkinson; Victoria Shingler; Gipsi Lima Mendez; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Bioinformatics; Alarmones; Evolution; Gene neighbourhood; Toxin; Antitoxin; molekylärbiologi; Molecular Biology;

   Sammanfattning : Bacteria experience a wide range of natural challenges during their life cycles, to which they must respond and adapt to live. Under stressed conditions such as amino acid starvation, bacteria slow down their growth mechanism by producing small alarmone nucleotides guanosine pentaphosphate (pppGpp) and tetraphosphate (ppGpp), collectively referred to as (p)ppGpp. LÄS MER

3. 2. Too close for comfort : The role of Contact-Dependent growth Inhibition (CDI) in interbacterial competition and cooperation

   Författare :Marcus Wäneskog; Sanna Koskiniemi; Paul Rainey; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bacterial interactions; cell-cell binding; contact-dependent growth inhibition; CDI; CdiB; CdiA; CdiI; outer-membrane receptor; BamA; OmpC; OmpF; extracellular toxin delivery; Toxin-Antitoxin; TA-system; persister cells; stress tolerance; stress response; rpoS; rssB; quorum sensing; multicellular behavior; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

   Sammanfattning : Contact-Dependent growth inhibition (CDI) was discovered in 2005 in the E. coli isolate EC93. Since then our knowledge of CDI systems and their impact on bacterial communities have increased exponentially. LÄS MER

4. 3. Novel RelA-SpoT Homolog toxin-antitoxin systems that inhibit bacterial growth through production of toxic alarmone ppApp

   Författare :Steffi Jimmy; Vasili Hauryliuk; Vicky Shingler; Michael T. Laub; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; p ppGpp; ppApp; toxin; antitoxin; alarmone; antibacterials; molekylärbiologi; Molecular Biology; Biochemistry; biokemi;

   Sammanfattning : The stress alarmone nucleotides guanosine pentaphosphate (pppGpp) and tetraphosphate (ppGpp), collectively known as (p)ppGpp, are the molecular mediators of the bacterial stringent response — a bacterial stress response implicated in virulence, antibiotic tolerance and biofilm formation. At high concentrations, (p)ppGpp halts bacterial growth, inhibits protein synthesis and rewires transcription and metabolism. LÄS MER

5. 4. To defend or to offend? : Bacterial defence and competition systems

   Författare :Danna Lee; Sanna Koskiniemi; Marjan van der Woude; Uppsala universitet; []
   Nyckelord :bacterial defence systems; bacterial competition systems; toxin-antitoxin systems; colicin; contact-dependent growth inhibition CDI ; type VI secretion system T6SS ; Rearrangement hotspot Rhs proteins; CRISPR; horizontal gene transfer; antibiotic resistance; Salmonella; Enterotoxigenic E. coli ETEC ; probiotics; synthetic biology.;

   Sammanfattning : Bacteria are prokaryotic microorganisms that can be found in all niches of the biosphere. Bacteria must constantly evolve in order to survive and adapt to their environments. Defence systems and competition systems play a vital role in ensuring the survival of bacteria. LÄS MER

7. 5. Unlocking protein sequences : Advances in protein structure and ligand-binding site prediction

   Författare :Aditi Shenoy; Arne Elofsson; Geoffrey J Barton; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

   Sammanfattning : The protein sequence determines how it will fold into its unique three-dimensional structure. Once folded, proteins perform their functions by interacting with other proteins or molecules called ligands within the cell. Experimental determination of protein structure and function is tedious. LÄS MER