Sökning: "toxikologi"

Visar resultat 6 - 10 av 333 avhandlingar innehållade ordet toxikologi.

  1. 6. Pluripotent Stem Cells of Embryonic Origin Applications in Developmental Toxicology

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Måns Jergil; Uppsala universitet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Embryonic stem cell; Microarray; Toxicogenomics; Valproic acid; Developmental toxicology; Teratogenicity; Neural tube defects; Histone deacetylase inhibitor; In vitro toxicology; PHARMACY Toxicology; FARMACI Toxikologi; Toxicology; Toxikologi;

    Sammanfattning : General toxicity evaluation and risk assessment for human exposure is essential when developing new pharmaceuticals and chemicals. Developmental toxicology is an important part of this risk assessment which consumes large resources and many laboratory animals. LÄS MER

  2. 7. Distribution and Long-term Effects of the Environmental Neurotoxin β-N-methylamino-L-alanine (BMAA) Brain changes and behavioral impairments following developmental exposure

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Oskar Karlsson; Uppsala universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS PDC; Guam; Developmental neurotoxicity; Brain growth spurt; Behavior; Nonprotein amino acid; Excitotoxic; Cyanobacteria; Apoptosis; BMAA; environmental toxin; Algal blooming; Algblomning; algtoxin; alggift; hjärnutveckling; PHARMACY Toxicology; FARMACI Toxikologi; Toxicology; Toxikologi;

    Sammanfattning : Many cyanobacteria are reported to produce the nonprotein amino acid β-N-methylamino-L-alanine (BMAA). Cyanobacteria are extensively distributed in terrestrial and aquatic environments and recently BMAA was detected in temperate aquatic ecosystems, e.g. the Baltic Sea. LÄS MER

  3. 8. Developmental Neurotoxicity Testing Using In vitro Approaches

    Detta är en avhandling från Stockholm : The Wenner-Gren Institute, Stockholm University

    Författare :Helena Högberg; Stockholms universitet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE Physiology and pharmacology Pharmacological research Toxicology; MEDICIN Fysiologi och farmakologi Farmakologisk forskning Toxikologi; toxikologi; Toxicology;

    Sammanfattning : There is a great concern about children’s health as the developing brain in foetuses and children is much more vulnerable to injury caused by different classes of chemicals than the adult brain. This vulnerability is partly due to the fact that the adult brain is well protected against chemicals by the blood brain barrier (BBB) and children have increased absorption rates and diminished ability to detoxify many exogenous compounds, in comparison to that of adults. LÄS MER

  4. 9. Formation and metabolism of the tryptophan-derived 6-formylindolo[3,2-b]carbazole - a light-induced Ah-receptor ligand

    Detta är en avhandling från Stockholm : Institutionen för genetik, mikrobiologi och toxikologi

    Författare :Linda Bergander; Stockholms universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY Toxicology; FARMACI Toxikologi;

    Sammanfattning : The aryl hydrocarbon receptor (AhR) is a ligand dependent transcription factor ubiquitously expressed in mammalian cells. It is a genetically ancient protein mostly known for binding the extremely toxic contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). LÄS MER

  5. 10. Involvement of Homologous Recombination in Response to Different Qualities of DNA Damage

    Detta är en avhandling från Stockholm : Institutionen för genetik, mikrobiologi och toxikologi

    Författare :Gunilla Olsson; Stockholms universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY Toxicology; FARMACI Toxikologi;

    Sammanfattning : The present studies aimed at elucidate the role of homologous recombination (HR) for the repair of different qualities of DNA damages and/or changes in chromatin structure induced by a variety of radiation qualities.Radiation qualities used to expose cells in culture ranged from non-ionizing radiation with extremely low frequency (ELF), of energies too low to disrupt chemical or molecular bonds, to radiation qualities with energies able to induce ionizations and break chemical bonds. LÄS MER