Sökning: "toxicology"

Visar resultat 21 - 25 av 384 avhandlingar innehållade ordet toxicology.

  1. 21. Tissue-Selective Activation and Toxicity of Substituted Dichlorobenzenes : Studies on the Mechanism of Cell Death in the Olfactory Mucosa

    Författare :Anna Franzén; Eva Brittebo; Ingvar Brandt; Olavi Pelkonen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; tissue-selective toxicity; bioactivation; olfactory mucosa; substituted dichlorobenzenes; Bowman s glands; sustentacular cells; ER stress; Grp78; caspase-12; caspase-3; CYP2A5; protein adduction; nasal toxicity; Toxikologi; Toxicology; Toxikologi;

    Sammanfattning : The nasal passages are constantly exposed to both air- and bloodborne foreign compounds. In particular, the olfactory mucosa is demonstrated to be susceptible to a variety of drugs and chemicals. LÄS MER

  3. 22. Cannabinoids as modulators of cancer cell viability, neuronal differentiation, and embryonal development

    Författare :Sofia Gustafsson; Stig Jacobsson; Birgitta Sander; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cannabinoids; cell viability; neuronal differentiation; colorectal cancer; chick embryo; biokemisk farmakologi; biochemical pharmacology; Toxicology; toxikologi;

    Sammanfattning : Cannabinoids (CBs) are compounds that activate the CB1 and CB2 receptors. CB receptors mediate many different physiological functions, and cannabinoids have been reported to decrease tumor cell viability, proliferation, migration, as well as to modulate metastasis. LÄS MER

  4. 23. Biomarkers of oxidative stress and their application for assessment of individual radiosensitivity

    Författare :Siamak Haghdoost; Mats Harms-Ringdahl; Steffen Loft; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oxidative stress; 8-oxo-dG; 8-oh-dG; Radiosensitivity; Toxicology; Toxikologi;

    Sammanfattning : Radiotherapy is one of the most common therapeutic methods for treatment of many types of cancer. Despite many decades of development and experience there is much to improve, both in efficacy of treatment and to decrease the incidences of adverse healthy tissue reactions. LÄS MER

  5. 24. Effects of organo-halogenated compounds on the thyroid hormone system in rodents

    Författare :Sara Hallgren; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Toxikologi;

    Sammanfattning : .... LÄS MER

  7. 25. Developmental Neurotoxicity Testing Using In vitro Approaches

    Författare :Helena Högberg; Anna Price; Barbara Cannon; Kevin Crofton; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Toxikologi; toxikologi; Toxicology;

    Sammanfattning : There is a great concern about children’s health as the developing brain in foetuses and children is much more vulnerable to injury caused by different classes of chemicals than the adult brain. This vulnerability is partly due to the fact that the adult brain is well protected against chemicals by the blood brain barrier (BBB) and children have increased absorption rates and diminished ability to detoxify many exogenous compounds, in comparison to that of adults. LÄS MER