Sökning: "toxicity testing"
Visar resultat 11 - 15 av 68 avhandlingar innehållade orden toxicity testing.
11. Toxicity pathways in zebrafish cell lines : an ecotoxicological perspective on ”toxicity testing in the 21st century”
Sammanfattning : Standard toxicological in vivo testing has been challenged as the procedures are time-consuming, expensive, and require a large number of animals; given the number of problematic chemicals. Novel toxicological frameworks, such as "toxicity testing in the 21st century", proposed the use of "new approach methods" (in vitro and in silico techniques), that can be applied in high-throughput setups and would allow for the testing of a large number of compounds. LÄS MER
12. A step forward in using QSARs for regulatory hazard and exposure assessment of chemicals
Sammanfattning : According to the REACH regulation chemicals produced or imported to the European Union need to be assessed to manage the risk of potential hazard to human health and the environment. An increasing number of chemicals in commerce prompts the need for utilizing faster and cheaper alternative methods for this assessment, such as quantitative structure-activity or property relationships (QSARs or QSPRs). LÄS MER
13. New Approaches for Daphnia magna Toxicity Assessment
Sammanfattning : Risk assessment plays a crucial role in evaluating and managing the potential hazards and health effects associated with exposure to substances. In recent decades, the field of risk assessment has undergone significant expansion, embracing innovative approaches and methodologies. LÄS MER
14. Developmental Neurotoxicity Testing Using In vitro Approaches
Sammanfattning : There is a great concern about children’s health as the developing brain in foetuses and children is much more vulnerable to injury caused by different classes of chemicals than the adult brain. This vulnerability is partly due to the fact that the adult brain is well protected against chemicals by the blood brain barrier (BBB) and children have increased absorption rates and diminished ability to detoxify many exogenous compounds, in comparison to that of adults. LÄS MER
15. Exploring the SPR methodology for monitoring of critical attributes in toxicity testing and bioproduction
Sammanfattning : Analysis of biological components is central in bioprocess monitoring, process control, product quality control and cell based toxicity assaying. One of these themes that is pursued in this thesis is the use of biosensors for monitoring of molecular markers, exploiting the natural selectivity of biomolecules. LÄS MER
