Sökning: "toxicity effects"

Visar resultat 1 - 5 av 486 avhandlingar innehållade orden toxicity effects.

1. 1. Pathogenic effects of alpha-synuclein: modifications and toxicity

   Författare :Natalie Landeck; Brain Repair and Imaging in Neural Systems (BRAINS); []
   Nyckelord :Parkinson s disease; adeno-associated viral vector; animal models; alpha-synuclein; substantia nigra; dopaminergic neurons; phosphorylation; aggregation; toxicity;

   Sammanfattning : Accumulation of intraneuronal inclusions, containing mainly a protein called alpha-synuclein (asyn), is thought to play a critical role in neurodegenerative disorders such as Parkinson's disease (PD). In these so called Lewy bodies, the majority of asyn is phosphorylated at serine 129 (pS129) suggesting that post-translational modifications may play a critical role in the process of aggregate formation. LÄS MER

3. 2. Uptake and toxicity of brominated flame retardants and pesticides : Studies on littoral organisms and model communities

   Författare :Kerstin Gustafsson; Nils Kautsky; Kirsten Christoffersen; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; aquatic ecotoxicology; ecological interactions; indirect effects; model community studies; toxicity; Terrestrial; freshwater and marine ecology; Terrestisk; limnisk och marin ekologi;

   Sammanfattning : In this thesis, brackish and freshwater littoral model communities (microcosms) of varying size and complexity were used to study the effects of brominated flame retardants (BFRs) and pesticides. The brackish water microcosms consisted of natural water, sediment and associated organisms, while the larger freshwater microcosms also contained submersed macrophytes (Elodea canadensis). LÄS MER

4. 3. Anthracyclines : Toxicity and chemotherapy-induced mucositis

   Författare :Fredrik Kullenberg; Hans Lennernäs; Erik Sjögren; David Dahlgren; Femke Heindryckx; Henrik Rönnberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anthracycline; doxorubicin; idarubicin; toxicity; intracellular concentration; IC50; chemotherapy-induced mucositis; apoptosis; proliferation; permeability; anti-inflammatory drugs; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Anthracyclines belong to a class of cytostatic compounds that are commonly used to treat various types of cancers, including lymphoma, breast cancer and primary liver cancer. The aim of this thesis was to study how two anthracyclines, doxorubicin and idarubicin, induced cytotoxicity in tumor cells, as well as their off-target effect on the gastrointestinal system. LÄS MER

5. 4. Comparative avian developmental toxicity of PFAAs

   Författare :Marcus Nordén; Magnus Engwall; Krister Halldin; Anders Bignert; Örebro universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; chicken; herring gull; cormorant; PFAA; PFOS; PFOA; toxicity; levels; Biology; Biologi;

   Sammanfattning : Perfluoroalkyl acids (PFAAs) are persistent organic pollutants that can commonly be found in environmental matrixes and wildlife from all over the globe. The PFAAs have been used in applications such as water and dirt repelling treatments for textiles, oil-resistant paper coatings and fire-fighting foams. LÄS MER

7. 5. Analysis of Perfluoroalkyl Acids in Swedish Biota : Temporal trends, tissue distribution and toxicity

   Författare :Katrin Holmström; Urs Berger; Gregg Tomy; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Environmental chemistry; PFOS; PFAS; pollutant; Baltic guillemot; peregrine falcon; Monoporeia affinis; time trend; toxicity; Environmental chemistry; Miljökemi; Persistent organic compounds; Persistenta organiska föreningar; Applied Environmental Science; tillämpad miljövetenskap;

   Sammanfattning : Perfluorinated alkyl acids (PFAS) are ubiquitous environmental contaminants. They are found in high concentrations in top predators worldwide, with perfluorooctane sulfonate (PFOS) as the predominant compound. LÄS MER